{"doi":"10.1016/j.nutres.2015.12.002","title":"Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice","abstract":null,"journal":"Nutrition Research","year":2016,"id":686592,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1793720,"name":"Juliang Qin","orcid":null,"position":1,"is_corresponding":false},{"id":979849,"name":"Yihan Zhao","orcid":"0000-0002-8182-8437","position":2,"is_corresponding":false},{"id":1793721,"name":"Jueping Shi","orcid":null,"position":3,"is_corresponding":false},{"id":1793722,"name":"Rong Lan","orcid":null,"position":4,"is_corresponding":false},{"id":1793723,"name":"Yunqiu Gan","orcid":null,"position":5,"is_corresponding":false},{"id":769400,"name":"Hua Ren","orcid":"0000-0002-8809-7972","position":6,"is_corresponding":false},{"id":57460,"name":"Bing Zhu","orcid":null,"position":7,"is_corresponding":false},{"id":890310,"name":"Min Qian","orcid":"0000-0003-1214-8830","position":8,"is_corresponding":false},{"id":243288,"name":"Bing Du","orcid":"0000-0002-5402-6527","position":9,"is_corresponding":false},{"id":277248,"name":"Xiaoyu Zhang","orcid":"0000-0002-0951-9664","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice","abstract":"The ketogenic diet (KD) has been widely used in weight and glycemic control, although potential side effects of long-term KD treatment have caused persistent concern. In this study, we hypothesized that the KD would ameliorate the progression of diabetes but lead to disruptions in lipid metabolism and hepatic steatosis in a mouse model of diabetes. In type 2 diabetic mouse model, mice were fed a high-fat diet and administered streptozotocin treatment before given the test diets for 8 weeks. Subsequently, ameliorated glucose and insulin tolerance in KD-fed diabetic mice was found, although the body weight of high-fat diet- and KD-fed mice was similar. Interestingly, the weight of adipose tissue in KD mice was greater than in the other groups. The KD diet resulted in higher serum triacylglycerol and cholesterol levels in diabetic mice. Moreover, the KD-fed mice showed greater hepatic lipid accumulation. Mice fed the KD showed significant changes in several key genes such as sterol regulatory element-binding protein, fibroblast growth factor 21, and peroxisome proliferator-activated receptor α, which are all important in metabolism. In summary, KD ameliorates glucose and insulin tolerance in a mouse model of diabetes, but severe hepatic lipid accumulation and hepatic steatosis were observed, which should be considered carefully in the long-term application of KD.","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27001280","pmcid":null,"openalex_id":"https://openalex.org/W2192244866","authors":[],"funders":[],"total_grants":0,"fwci":1.7923,"citation_percentile":0.84632692,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":6},{"year":2019,"count":4},{"year":2020,"count":8},{"year":2021,"count":9},{"year":2022,"count":3},{"year":2023,"count":9},{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":5}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0271531715003012?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0271531715003012?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.nutres.2015.12.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27001280","host_type":"repository"}],"fields_of_study":["Diet and metabolism studies","Diet, Metabolism, and Disease","Adipose Tissue and Metabolism","Animals","Blood Glucose","Diabetes Mellitus, Experimental","Diabetes Mellitus, Type 2","Diet, Ketogenic","Fatty Liver","Fibroblast Growth Factors","Glucose Intolerance","Glucose Tolerance Test","Lipid Metabolism","Liver","Male","Mice","Mice, Inbred C57BL","PPAR alpha","RNA, Messenger","Sterol Regulatory Element Binding Proteins"],"mesh_terms":["Animals","Blood Glucose","Diabetes Mellitus, Experimental","Diabetes Mellitus, Type 2","Fatty Liver","Fibroblast Growth Factors","Glucose Tolerance Test","Liver","Male","Mice, Inbred C57BL","RNA, Messenger","Glucose Intolerance","PPAR alpha","Lipid Metabolism","Mice","Sterol Regulatory Element Binding Proteins","Diet, Ketogenic"],"keywords":["Endocrinology","Internal medicine","Steatosis","Adipose tissue","Insulin","Lipid metabolism","Diabetes mellitus","Ketogenic diet","FGF21","Fatty liver","Biology","Type 2 diabetes","Glycemic","Streptozotocin","Medicine","Receptor","Fibroblast growth factor","Lipid accumulation","Glycemic control","hepatic steatosis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T19:55:37.681714Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}