{"doi":"10.1016/j.nut.2017.11.004","title":"Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig","abstract":null,"journal":"Nutrition","year":2018,"id":619710,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1599445,"name":"Didier Rémond","orcid":null,"position":1,"is_corresponding":false},{"id":1599446,"name":"Jérémie David","orcid":null,"position":2,"is_corresponding":false},{"id":1599447,"name":"Dominique Dardevet","orcid":null,"position":3,"is_corresponding":false},{"id":1599448,"name":"Isabelle Savary-Auzeloux","orcid":null,"position":4,"is_corresponding":false},{"id":1599444,"name":"Sergio Polakof","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig","abstract":"<h4>Objectives</h4>High-fat high-sucrose diet (HFHS) overfeeding is one of the main factors responsible for the increased prevalence of metabolic disorders. Elevated levels of branched-chain amino acids (BCAAs) have been associated with metabolic dysfunctions, including insulin resistance (IR). The aim of this study was to elucidate whether elevated BCAA levels are the cause or the consequence of IR and to determine the mechanisms and tissues involved in such a phenotype.<h4>Methods</h4>We performed a 2-mo follow-up on minipigs overfed an HFHS diet and focused on kinetics fasting and postprandial (PP) BCAA levels and BCAA catabolism in key tissues.<h4>Results</h4>The study of the fasting BCAA elevation reveals that BCAA accumulation in the plasma compartment is well correlated with IR markers and body weight. Furthermore, the PP excursion of BCAA levels after the last HFHS meal was exacerbated when compared with that of the first meal, suggesting a reduced amino acid oxidation potential. Although only minor changes in BCAA metabolism were observed in liver, muscle, and the visceral adipose tissue, the oxidative deamination potential of the subcutaneous adipose tissue was blunted after 60 d of HFHS feeding.<h4>Conclusions</h4>To our knowledge, the present results demonstrated for the first time in a swine model of obesity and IR, the existence of a phenotype related to high-circulating BCAA levels and metabolic dysregulation. The oxidative BCAA capacity reduction specifically in the subcutaneous adipose tissue emerges, at least in the present swine model, as the more plausible metabolic explanation for the elevated blood BCAA phenotype.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29547796","pmcid":null,"openalex_id":"https://openalex.org/W2769209287","authors":[],"funders":[],"total_grants":0,"fwci":1.5896,"citation_percentile":0.83088085,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0899900717302472","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0899900717302472","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0899900717302472?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0899900717302472?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.nut.2017.11.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29547796","host_type":"repository"},{"url":"https://hal.science/hal-01741289","host_type":"repository"}],"fields_of_study":["Diet and metabolism studies","Fatty Acid Research and Health","Metabolomics and Mass Spectrometry Studies"],"mesh_terms":["Amino Acids","Amino Acids, Branched-Chain","Animals","Disease Models, Animal","Fasting","Insulin Resistance","Male","Obesity","Oxidation-Reduction","Swine","Swine, Miniature","Time Factors","Dietary Sucrose","Postprandial Period","Subcutaneous Fat","Intra-Abdominal Fat","Diet, High-Fat"],"keywords":["Internal medicine","Endocrinology","Postprandial","Adipose tissue","Branched-chain amino acid","Catabolism","Metabolism","Oxidative deamination","Amino acid","Biology","Obesity","Insulin resistance","Chemistry","Insulin","Medicine","Biochemistry","Leucine","minipig","Branched-chain Amino Acids"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T08:10:50.855033Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}