{"doi":"10.1016/j.numecd.2021.09.013","title":"Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors","abstract":"BACKGROUND AND AIMS: Recent evidence links trimethylamine oxide (TMAO) to endothelial dysfunction, an early indicator of cardiovascular disease. We aimed to determine whether short-term consumption of a diet patterned after the 2010 Dietary Guidelines for Americans (DGA) would affect endothelial function, plasma TMAO concentrations, and cardiovascular disease risk, differently than a typical American Diet (TAD). METHODS AND RESULTS: An 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 ± 4.0 vs. wk8: 50.5 ± 3.1 (p = 0.05), vs. TAD wk8: 47.7 ± 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks. CONCLUSION: Consumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. CLINICALTRIALS.GOV: NCT02298725.","journal":"Nutrition Metabolism and Cardiovascular Diseases","year":2021,"id":189394,"datarank":0.8651249034518977,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.44923659511593045,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.44923659511593045,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":15,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02298725"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":535944,"name":"Erik Gertz","orcid":null,"position":1,"is_corresponding":false},{"id":273743,"name":"Sean H. Adams","orcid":"0000-0002-9515-2319","position":2,"is_corresponding":false},{"id":245218,"name":"John W. Newman","orcid":"0000-0001-9632-6571","position":3,"is_corresponding":false},{"id":349079,"name":"Theresa L. Pedersen","orcid":null,"position":4,"is_corresponding":false},{"id":474608,"name":"Nancy L. Keim","orcid":"0000-0002-6601-7572","position":5,"is_corresponding":false},{"id":400044,"name":"Brian J. Bennett","orcid":"0000-0002-0766-3195","position":6,"is_corresponding":false},{"id":535331,"name":"Sridevi Krishnan","orcid":"0000-0003-2757-6934","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T23:49:18.604374Z","pmid":"34895998","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}