{"doi":"10.1016/j.neuropharm.2016.07.027","title":"Severe stress hormone conditions cause an extended window of excitability in the mouse basolateral amygdala","abstract":null,"journal":"Neuropharmacology","year":2016,"id":642571,"datarank":1.0844204584658752,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.516792013378136,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.516792013378136,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":30,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":634184,"name":"Marian Joëls","orcid":"0000-0002-4826-6209","position":1,"is_corresponding":false},{"id":1222751,"name":"Henk Karst","orcid":"0000-0003-2283-5642","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Severe stress hormone conditions cause an extended window of excitability in the mouse basolateral amygdala","abstract":"Shortly after stress, basolateral amygdala neurons are exposed to sequential yet partly overlapping waves of hormones. We examined how these hormonal waves can change activity of basolateral amygdala neurons such that emotional aspects of stress become so deeply ingrained. To this end, spontaneous glutamatergic transmission was recorded during and up to several hours after combined adrenergic and corticosteroid waves, targeting the time-window relevant for encoding of stress-related information. Hormonal waves mimicking moderately stressful conditions cause a transient enhancement followed by later suppression of glutamatergic transmission. However, this late phase flips from suppressed to enhanced glutamatergic transmission with conditions mimicking severe stress. Such a prolonged window of enhanced excitability may contribute to the excessively strong encoding seen after the experience of highly stressful or traumatic events.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27460963","pmcid":null,"openalex_id":"https://openalex.org/W2481292504","authors":[],"funders":[],"total_grants":0,"fwci":2.2375,"citation_percentile":0.8708134,"influential_citations":0,"citation_trend":[{"year":2017,"count":6},{"year":2018,"count":6},{"year":2019,"count":5},{"year":2020,"count":7},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0028390816303136?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0028390816303136?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuropharm.2016.07.027","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27460963","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/338728","host_type":"repository"},{"url":"http://dspace.library.uu.nl/handle/1874/338728","host_type":"repository"}],"fields_of_study":["Stress Responses and Cortisol","Neuroendocrine regulation and behavior","Tryptophan and brain disorders","Animals","Basolateral Nuclear Complex","Corticosterone","Dose-Response Relationship, Drug","Excitatory Postsynaptic Potentials","Isoproterenol","Male","Mice","Mice, Inbred C57BL","Organ Culture Techniques","Stress, Psychological"],"mesh_terms":["Animals","Corticosterone","Dose-Response Relationship, Drug","Isoproterenol","Male","Mice, Inbred C57BL","Organ Culture Techniques","Stress, Psychological","Excitatory Postsynaptic Potentials","Mice","Basolateral Nuclear Complex"],"keywords":["Basolateral amygdala","Glutamatergic","Neuroscience","Hormone","Amygdala","Excitatory postsynaptic potential","Psychology","Endocrinology","Medicine","Internal medicine","Inhibitory postsynaptic potential","Glutamate receptor","Receptor","Noradrenaline","Corticosterone","Ptsd","Consolidation","Metaplasticity","Mepsc"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T00:19:01.980138Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}