{"doi":"10.1016/j.neuron.2025.10.035","title":"Biased histamine signaling selectively gates fat preference","abstract":null,"journal":"Neuron","year":2026,"id":641093,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":920852,"name":"Jie Liao","orcid":"0000-0002-6697-8998","position":1,"is_corresponding":false},{"id":1666577,"name":"Zhuowen Fang","orcid":null,"position":2,"is_corresponding":false},{"id":1333028,"name":"Xinyan Tang","orcid":null,"position":3,"is_corresponding":false},{"id":1666578,"name":"Zhuchen Zhou","orcid":null,"position":4,"is_corresponding":false},{"id":645431,"name":"Xinyue Zhao","orcid":null,"position":5,"is_corresponding":false},{"id":1173518,"name":"Menghan Li","orcid":"0000-0002-1412-4456","position":6,"is_corresponding":false},{"id":1396844,"name":"Mengting Liu","orcid":"0000-0001-9167-733X","position":7,"is_corresponding":false},{"id":700710,"name":"Shujun Xu","orcid":"0000-0002-2752-5507","position":8,"is_corresponding":false},{"id":689239,"name":"Jiahui Chen","orcid":"0000-0003-4299-2688","position":9,"is_corresponding":false},{"id":886154,"name":"Lingyu Xu","orcid":"0000-0001-6145-8371","position":10,"is_corresponding":false},{"id":710398,"name":"Yi Wang","orcid":"0000-0001-8043-4869","position":11,"is_corresponding":false},{"id":367401,"name":"Yan Zhang","orcid":"0000-0002-6041-4454","position":12,"is_corresponding":false},{"id":749416,"name":"Weiwei Hu","orcid":"0000-0001-6916-3746","position":13,"is_corresponding":false},{"id":385235,"name":"Zhong Chen","orcid":"0000-0003-2957-3841","position":14,"is_corresponding":false},{"id":1666576,"name":"Yanrong Zheng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biased histamine signaling selectively gates fat preference","abstract":"Fat poses a serious challenge to healthy dietary management due to its unique palatability and high energy density. Previous studies indicate that sugar and fat are independently perceived in the periphery, yet identifying molecular targets for selectively regulating fat preference remains a challenge. Here, using neuronal activity-dependent labeling, we identified a striking separation between high-fat-diet (HFD)- and high-sugar-diet (HSD)-responsive neuronal populations in the paraventricular thalamus (PVT). Translating ribosome affinity purification sequencing and in situ hybridization further revealed the histamine H3 receptor (H<sub>3</sub>R) as a marker of PVT<sup>HFD</sup> neurons. Manipulating H<sub>3</sub>R expression or histaminergic terminals in the PVT specifically modulated HFD consumption. These histaminergic projections regulate fat consumption in response to oral dietary cues. Electrophysiological analyses demonstrated that histamine-mediated H<sub>3</sub>R activation enhances PVT<sup>HFD</sup> neuronal excitability via biased G<sub>12/13</sub> signaling. These findings establish a novel role for the PVT in gating fat preference and identify the H<sub>3</sub>R-G<sub>12/13</sub> axis as a potential target for precise fat-consumption control.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41308645","pmcid":null,"openalex_id":"https://openalex.org/W4416702143","authors":[],"funders":[{"funder_name":"Key Technologies Research and Development Program","grant_id":"2019YFA050880","title":null},{"funder_name":"National Major Science and Technology Projects of China","grant_id":"2024ZD0530704","title":null},{"funder_name":"National Major Science and Technology Projects of China","grant_id":"2021ZD0202803","title":null},{"funder_name":"Zhejiang Province Natural Science Foundation","grant_id":"LD25H090002","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"U21A20418","title":null},{"funder_name":"National Science and Technology Major Project","grant_id":"","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"","title":null}],"total_grants":7,"fwci":0.4044,"citation_percentile":0.6488271,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0896627325008426?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627325008426?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuron.2025.10.035","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41308645","host_type":"repository"}],"fields_of_study":["Mast cells and histamine","Regulation of Appetite and Obesity","Olfactory and Sensory Function Studies","Medicine","Biology","Animals","Histamine","Signal Transduction","Mice","Receptors, Histamine H3","Diet, High-Fat","Male","Neurons","Food Preferences","Mice, Inbred C57BL"],"mesh_terms":["Animals","Food Preferences","Histamine","Male","Mice, Inbred C57BL","Neurons","Signal Transduction","Receptors, Histamine H3","Mice","Diet, High-Fat"],"keywords":["Histaminergic","Histamine","Conditioned place preference","Palatability","Electrophysiology","Optogenetics","Photostimulation","Thalamus","Taste","Histamine H3 Receptor","Fat Preference","Paraventricular Thalamus","Sugar Preference","Biased Gpcr Signaling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T15:52:02.599313Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}