{"doi":"10.1016/j.neuron.2025.02.009","title":"The predictive nature of spontaneous brain activity across scales and species","abstract":null,"journal":"Neuron","year":2025,"id":643835,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":625534,"name":"Giovanni Pezzulo","orcid":"0000-0001-6813-8282","position":1,"is_corresponding":false},{"id":694244,"name":"Andrea Zangrossi","orcid":"0000-0001-7832-1953","position":2,"is_corresponding":false},{"id":15949,"name":"Maurizio Corbetta","orcid":"0000-0001-8295-3304","position":3,"is_corresponding":false},{"id":1675467,"name":"Anastasia Dimakou","orcid":"0000-0003-4768-9215","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The predictive nature of spontaneous brain activity across scales and species.","abstract":"Emerging research suggests the brain operates as a \"prediction machine,\" continuously anticipating sensory, motor, and cognitive outcomes. Central to this capability is the brain's spontaneous activity-ongoing internal processes independent of external stimuli. Neuroimaging and computational studies support that this activity is integral to maintaining and refining mental models of our environment, body, and behaviors, akin to generative models in computation. During rest, spontaneous activity expands the variability of potential representations, enhancing the accuracy and adaptability of these models. When performing tasks, internal models direct brain regions to anticipate sensory and motor states, optimizing performance. This review synthesizes evidence from various species, from C. elegans to humans, highlighting three key aspects of spontaneous brain activity's role in prediction: the similarity between spontaneous and task-related activity, the encoding of behavioral and interoceptive priors, and the high metabolic cost of this activity, underscoring prediction as a fundamental function of brains across species.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40101720","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"820213","title":"Thinking Ahead: human planning from a predictive processing perspective"},{"funder_name":"European Commission","grant_id":"PE0000006","title":null},{"funder_name":"Horizon 2020","grant_id":"869505","title":"VISIONARY NATURE BASED ACTIONS FOR HEALTH, WELLBEING & RESILIENCE IN CITIES (VARCITIES)"},{"funder_name":"European Commission","grant_id":"PE0000013","title":null},{"funder_name":"European Commission","grant_id":"CUP B51E22000150006","title":null},{"funder_name":"Ministero dell'Università e della Ricerca","grant_id":"PRIN 20229Z7M8N","title":null},{"funder_name":"Ministero dell’Istruzione, dell’Università e della Ricerca","grant_id":"PRIN PNRR P20224FESY","title":null},{"funder_name":"Horizon 2020","grant_id":"952215","title":null},{"funder_name":"Ministry of Health","grant_id":"RF-2018-1236689","title":null},{"funder_name":"Ministry of Health","grant_id":"RF-2019-12369300","title":null},{"funder_name":"European Research Executive Agency","grant_id":"860563","title":null},{"funder_name":"European Commission","grant_id":"101147319","title":"EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health"},{"funder_name":"European Commission","grant_id":"101071900","title":"NEurological MEchanismS of Injury, and Sleep-like  cellular dynamics"},{"funder_name":"Ministero dell'Istruzione dell'Università e della Ricerca","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Research Council","grant_id":"","title":null},{"funder_name":"Ministero dell'Istruzione dell'Università e della Ricerca","grant_id":"","title":null}],"total_grants":16,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.neuron.2025.02.009","host_type":"publisher"},{"url":"https://www.cell.com/neuron/fulltext/S0896-6273(25)00127-8?rss=yes","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40101720","host_type":""},{"url":"https://hdl.handle.net/11577/3550081","host_type":""},{"url":"http://dx.doi.org/10.1016/J.NEURON.2025.02.009","host_type":""},{"url":"http://dx.doi.org/10.1016/j.neuron.2025.02.009","host_type":""}],"fields_of_study":["05 social sciences","0501 psychology and cognitive sciences"],"mesh_terms":["Brain","Animals","Humans","Caenorhabditis elegans","Species Specificity","Models, Neurological"],"keywords":["Spontaneous Brain Activity","Predictive Brains","Behavioral Priors","Metabolic Priors","Task-rest Similarity","Species Specificity","Models, Neurological","Brain","Humans","Animals","spontaneous brain activity predictive brains behavioral priors task-rest similarity metabolic priors","Caenorhabditis elegans"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T19:11:56.638824Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}