{"doi":"10.1016/j.neuron.2024.12.013","title":"Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns","abstract":"Timed dopamine signals underlie reinforcement learning, favoring neural activity patterns that drive behaviors with positive outcomes. In the striatum, dopamine activates five dopamine receptors (D1R-D5R), which are differentially expressed in striatal neurons. However, the role of specific dopamine receptors in reinforcement is poorly understood. Using our cell-specific D1R photo-agonist, we find that D1R activation in D1-expressing neurons in the dorsomedial striatum is sufficient to reinforce preceding neural firing patterns in defined ensembles of layer 5 cortico-striatal neurons of the mouse motor cortex. The reinforcement is cumulative and time dependent, with an optimal effect when D1R activation follows the selected neural pattern after a short interval. Our results show that D1R activation in striatal neurons can selectively reinforce cortical activity patterns, independent of a behavioral outcome or a reward, crucially contributing to the fundamental mechanisms that support cognitive functions like learning, memory, and decision-making.","journal":"Neuron","year":2025,"id":515815,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1381203,"name":"Jonathan Read","orcid":null,"position":1,"is_corresponding":false},{"id":1381204,"name":"Samantha Boggiano","orcid":null,"position":2,"is_corresponding":false},{"id":815626,"name":"Belinda E. Hetzler","orcid":"0000-0002-0372-9126","position":3,"is_corresponding":false},{"id":737220,"name":"Zisis Peitsinis","orcid":"0000-0003-0736-8011","position":4,"is_corresponding":false},{"id":665672,"name":"Cherise Stanley","orcid":null,"position":5,"is_corresponding":false},{"id":274374,"name":"Meike Visel","orcid":"0000-0002-5033-3730","position":6,"is_corresponding":false},{"id":166216,"name":"Dirk Trauner","orcid":"0000-0002-6782-6056","position":7,"is_corresponding":false},{"id":665066,"name":"Prashant Donthamsetti","orcid":"0009-0006-6979-1180","position":8,"is_corresponding":false},{"id":228184,"name":"Jose M. Carmena","orcid":"0000-0002-0214-2489","position":9,"is_corresponding":false},{"id":288675,"name":"Stephan Lammel","orcid":"0000-0002-3350-3208","position":10,"is_corresponding":false},{"id":292946,"name":"Ehud Y. Isacoff","orcid":"0000-0003-4775-9359","position":11,"is_corresponding":false},{"id":822464,"name":"Nuria Vendrell-Llopis","orcid":"0000-0002-8618-4247","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:48:44.647022Z","pmid":"39814009","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}