{"doi":"10.1016/j.neuron.2024.06.004","title":"Cellular and circuit architecture of the lateral septum for reward processing","abstract":null,"journal":"Neuron","year":2024,"id":669250,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1747837,"name":"Shishi Lai","orcid":null,"position":1,"is_corresponding":false},{"id":1747838,"name":"Shaolei Jiang","orcid":null,"position":2,"is_corresponding":false},{"id":1424988,"name":"Fengling Li","orcid":"0000-0001-9670-2215","position":3,"is_corresponding":false},{"id":1747839,"name":"Kaige Sun","orcid":null,"position":4,"is_corresponding":false},{"id":1747840,"name":"Xiaocong Wu","orcid":null,"position":5,"is_corresponding":false},{"id":1747841,"name":"Kuikui Zhou","orcid":null,"position":6,"is_corresponding":false},{"id":877215,"name":"Yutong Liu","orcid":"0000-0002-7493-5859","position":7,"is_corresponding":false},{"id":1747842,"name":"Xiaofei Deng","orcid":null,"position":8,"is_corresponding":false},{"id":68840,"name":"Zijun Chen","orcid":null,"position":9,"is_corresponding":false},{"id":1197990,"name":"Fang Xu","orcid":"0000-0003-3126-532X","position":10,"is_corresponding":false},{"id":164907,"name":"Yu Xu","orcid":"0000-0002-0894-5311","position":11,"is_corresponding":false},{"id":1747843,"name":"Kunhua Wang","orcid":null,"position":12,"is_corresponding":false},{"id":50368,"name":"Gang Cao","orcid":"0000-0003-0761-7305","position":13,"is_corresponding":false},{"id":219924,"name":"Fuqiang Xu","orcid":null,"position":14,"is_corresponding":false},{"id":1747847,"name":"Guo-Qiang Bi","orcid":null,"position":15,"is_corresponding":false},{"id":271946,"name":"Yingjie Zhu","orcid":"0000-0002-0783-0897","position":16,"is_corresponding":false},{"id":1217227,"name":"Gaowei Chen","orcid":"0000-0003-4033-2811","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cellular and circuit architecture of the lateral septum for reward processing","abstract":"The lateral septum (LS) is composed of heterogeneous cell types that are important for various motivated behaviors. However, the transcriptional profiles, spatial arrangement, function, and connectivity of these cell types have not been systematically studied. Using single-nucleus RNA sequencing, we delineated diverse genetically defined cell types in the LS that play distinct roles in reward processing. Notably, we found that estrogen receptor 1 (Esr1)-expressing neurons in the ventral LS (LS<sup>Esr1</sup>) are key drivers of reward seeking via projections to the ventral tegmental area, and these neurons play an essential role in methamphetamine (METH) reward and METH-seeking behavior. Extended exposure to METH increases the excitability of LS<sup>Esr1</sup> neurons by upregulating hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, thereby contributing to METH-induced locomotor sensitization. These insights not only elucidate the intricate molecular, circuit, and functional architecture of the septal region in reward processing but also reveal a neural pathway critical for METH reward and behavioral sensitization.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38959892","pmcid":null,"openalex_id":"https://openalex.org/W4400239581","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82171492","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82101569","title":null},{"funder_name":"Ministry of Science and Technology of the People&apos;s Republic of China","grant_id":"2021ZD0202103","title":null},{"funder_name":"Ministry of Science and Technology of the People&apos;s Republic of China","grant_id":"2021ZD0203500","title":null},{"funder_name":"Fundo para o Desenvolvimento das Ciências e da Tecnologia","grant_id":"001/2020/ALC","title":null},{"funder_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","grant_id":"ZDSYS20190902093601675","title":null},{"funder_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","grant_id":"RCJC20200714114556103","title":null},{"funder_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","grant_id":"KQTD20210811090117032","title":null},{"funder_name":"Guangdong Provincial Department of Science and Technology","grant_id":"2023B1515040009","title":null},{"funder_name":"Guangdong Provincial Department of Science and Technology","grant_id":"2021B1515120020","title":null},{"funder_name":"Innovative Research Team of High-level Local University in Shanghai","grant_id":"","title":null}],"total_grants":11,"fwci":6.9584,"citation_percentile":0.98092811,"influential_citations":0,"citation_trend":[{"year":2024,"count":6},{"year":2025,"count":20},{"year":2026,"count":18}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0896627324004112?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627324004112?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuron.2024.06.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38959892","host_type":"repository"}],"fields_of_study":["Receptor Mechanisms and Signaling","Single-cell and spatial transcriptomics","Immune Cell Function and Interaction","Reward","Animals","Mice","Neurons","Methamphetamine","Septal Nuclei","Male","Ventral Tegmental Area","Estrogen Receptor alpha","Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","Neural Pathways","Mice, Inbred C57BL","Drug-Seeking Behavior"],"mesh_terms":["Animals","Male","Methamphetamine","Mice, Inbred C57BL","Neural Pathways","Neurons","Reward","Septal Nuclei","Ventral Tegmental Area","Estrogen Receptor alpha","Mice","Drug-Seeking Behavior","Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels"],"keywords":["Neuroscience","Nucleus","Biology","Cell type","Function (biology)","Nerve net","RNA","Cell","Cell biology","Gene","Genetics","methamphetamine","Reward Processing","Lateral Septum","Estrogen Receptor 1","In Situ Sequencing","Single-nucleus Rna Sequencing"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T14:43:14.420830Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}