{"doi":"10.1016/j.neuron.2024.01.014","title":"Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain","abstract":null,"journal":"Neuron","year":2024,"id":640959,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":135504,"name":"Yan-Jia Luo","orcid":null,"position":1,"is_corresponding":false},{"id":1376624,"name":"Wei-Kun Su","orcid":null,"position":2,"is_corresponding":false},{"id":753652,"name":"Jing Ge","orcid":"0009-0009-3664-7811","position":3,"is_corresponding":false},{"id":546745,"name":"Andrew Crowther","orcid":"0000-0001-9269-6188","position":4,"is_corresponding":false},{"id":1070697,"name":"Ze-Ka Chen","orcid":"0000-0002-1629-9882","position":5,"is_corresponding":false},{"id":406913,"name":"Lu Wang","orcid":"0000-0001-9833-7450","position":6,"is_corresponding":false},{"id":197452,"name":"Michael Lazarus","orcid":null,"position":7,"is_corresponding":false},{"id":1666150,"name":"Zi-Long Liu","orcid":null,"position":8,"is_corresponding":false},{"id":1548806,"name":"Wei-Min Qu","orcid":null,"position":9,"is_corresponding":false},{"id":1548812,"name":"Zhi-Li Huang","orcid":null,"position":10,"is_corresponding":false},{"id":290962,"name":"Yadong Li","orcid":"0000-0002-5977-8760","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain","abstract":"Chronic pain often leads to the development of sleep disturbances. However, the precise neural circuit mechanisms responsible for sleep disorders in chronic pain have remained largely unknown. Here, we present compelling evidence that hyperactivity of pyramidal neurons (PNs) in the anterior cingulate cortex (ACC) drives insomnia in a mouse model of nerve-injury-induced chronic pain. After nerve injury, ACC PNs displayed spontaneous hyperactivity selectively in periods of insomnia. We then show that ACC PNs were both necessary for developing chronic-pain-induced insomnia and sufficient to mimic sleep loss in naive mice. Importantly, combining optogenetics and electrophysiological recordings, we found that the ACC projection to the dorsal medial striatum (DMS) underlies chronic-pain-induced insomnia through enhanced activity and plasticity of ACC-DMS dopamine D1R neuron synapses. Our findings shed light on the pivotal role of ACC PNs in developing chronic-pain-induced sleep disorders.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38354737","pmcid":null,"openalex_id":"https://openalex.org/W4391799702","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32371028","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31871072","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82071491","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32300822","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32070984","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82020108014","title":null},{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"JP21zf0127005","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP22K21351","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP21H02802","title":null},{"funder_name":"Shanghai Municipal Health Commission","grant_id":"202340046","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"2018SHZDZX01","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null},{"funder_name":"Shanghai Jiao Tong University","grant_id":"","title":null}],"total_grants":13,"fwci":10.9949,"citation_percentile":0.99010664,"influential_citations":0,"citation_trend":[{"year":2024,"count":12},{"year":2025,"count":17},{"year":2026,"count":17}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S0896627324000400/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0896627324000400/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627324000400?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627324000400?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuron.2024.01.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38354737","host_type":"repository"}],"fields_of_study":["Pain Mechanisms and Treatments","Botulinum Toxin and Related Neurological Disorders","Pain Management and Placebo Effect","Mice","Animals","Gyrus Cinguli","Chronic Pain","Sleep Initiation and Maintenance Disorders","Pyramidal Cells"],"mesh_terms":["Animals","Gyrus Cinguli","Sleep Initiation and Maintenance Disorders","Pyramidal Cells","Mice","Chronic Pain"],"keywords":["Anterior cingulate cortex","Striatum","Neuroscience","Ventral striatum","Chronic pain","Dorsum","Cingulate cortex","Psychology","Insomnia","Thalamus","Medicine","Anatomy","Psychiatry","Central nervous system","Cognition","Dopamine","Sleep","Pyramidal neurons","Calcium imaging","Dopamine D1 Receptor","Dopamine D2 Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T14:50:18.448243Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}