{"doi":"10.1016/j.neuron.2023.04.028","title":"Local and long-distance organization of prefrontal cortex circuits in the marmoset brain","abstract":"The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC and found two contrasting corticocortical and corticostriatal projection patterns: \"patchy\" projections that formed many columns of submillimeter scale in nearby and distant regions and \"diffuse\" projections that spread widely across the cortex and striatum. Parcellation-free analyses revealed representations of PFC gradients in these projections' local and global distribution patterns. We also demonstrated column-scale precision of reciprocal corticocortical connectivity, suggesting that PFC contains a mosaic of discrete columns. Diffuse projections showed considerable diversity in the laminar patterns of axonal spread. Altogether, these fine-grained analyses reveal important principles of local and long-distance PFC circuits in marmosets and provide insights into the functional organization of the primate brain.","journal":"Neuron","year":2023,"id":318406,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9357,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660367,"name":"Henrik Skibbe","orcid":"0000-0002-2857-6023","position":1,"is_corresponding":false},{"id":812107,"name":"Ken Nakae","orcid":"0000-0003-4183-1532","position":2,"is_corresponding":false},{"id":812108,"name":"Hiroshi Abe","orcid":"0000-0002-9711-9715","position":3,"is_corresponding":false},{"id":63063,"name":"Noritaka Ichinohe","orcid":"0000-0002-8323-4552","position":4,"is_corresponding":false},{"id":580509,"name":"Muhammad Febrian Rachmadi","orcid":"0000-0003-1672-9149","position":5,"is_corresponding":false},{"id":581539,"name":"Jian Wang","orcid":"0000-0003-2291-640X","position":6,"is_corresponding":false},{"id":812663,"name":"Masafumi Takaji","orcid":null,"position":7,"is_corresponding":false},{"id":602335,"name":"Hiroaki Mizukami","orcid":"0000-0001-8954-874X","position":8,"is_corresponding":false},{"id":754632,"name":"Alexander Woodward","orcid":"0000-0003-3068-1401","position":9,"is_corresponding":false},{"id":812109,"name":"Rui Gong","orcid":"0000-0001-5112-5696","position":10,"is_corresponding":false},{"id":431854,"name":"Junichi Hata","orcid":"0000-0001-5833-444X","position":11,"is_corresponding":false},{"id":15950,"name":"David C. Van Essen","orcid":"0000-0001-7044-4721","position":12,"is_corresponding":false},{"id":269746,"name":"Hideyuki Okano","orcid":"0000-0001-7482-5935","position":13,"is_corresponding":false},{"id":660366,"name":"Shin Ishii","orcid":"0000-0001-9385-8230","position":14,"is_corresponding":false},{"id":812110,"name":"Tetsuo Yamamori","orcid":"0000-0001-5016-0078","position":15,"is_corresponding":false},{"id":812106,"name":"Akiya Watakabe","orcid":"0000-0002-8382-3840","position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"37196659","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}