{"doi":"10.1016/j.neuron.2023.01.017","title":"Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons","abstract":"Neurons perform input-output operations that integrate synaptic inputs with intrinsic electrical properties; these operations are generally constrained by the brevity of synaptic events. Here, we report that sustained firing of CA1 hippocampal fast-spiking parvalbumin-expressing interneurons (PV-INs) can be persistently interrupted for several hundred milliseconds following brief GABA A R-mediated inhibition in vitro and in vivo . A single presynaptic neuron could interrupt PV-IN firing, occasionally with a single action potential (AP), and reliably with AP bursts. Experiments and computational modeling reveal that the persistent interruption of firing maintains neurons in a depolarized, quiescent state through a cell-autonomous mechanism. Interrupted PV-INs are strikingly responsive to Schaffer collateral inputs. The persistent interruption of firing provides a disinhibitory circuit mechanism favoring spike generation in CA1 pyramidal cells. Overall, our results demonstrate that neuronal silencing can far outlast brief synaptic inhibition owing to the well-tuned interplay between neurotransmitter release and postsynaptic membrane dynamics, a phenomenon impacting microcircuit function.","journal":"Neuron","year":2023,"id":333654,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":989775,"name":"Erica R. Nebet","orcid":null,"position":1,"is_corresponding":false},{"id":680307,"name":"Manuel Valero","orcid":"0000-0001-7860-577X","position":2,"is_corresponding":false},{"id":989226,"name":"Monica Hanani","orcid":"0000-0003-1657-5012","position":3,"is_corresponding":false},{"id":313485,"name":"Robert Egger","orcid":"0000-0003-0849-6904","position":4,"is_corresponding":false},{"id":618112,"name":"Samantha B. Larsen","orcid":"0000-0001-6392-2350","position":5,"is_corresponding":false},{"id":681455,"name":"Katherine W. Eyring","orcid":"0000-0003-3443-3157","position":6,"is_corresponding":false},{"id":263225,"name":"György Buzsáki","orcid":"0000-0002-3100-4800","position":7,"is_corresponding":false},{"id":302095,"name":"Richard W. Tsien","orcid":"0000-0001-7428-9722","position":8,"is_corresponding":false},{"id":989225,"name":"Simon Chamberland","orcid":"0000-0003-2061-4109","position":0,"is_corresponding":true}],"reference_count":104,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:44.297718Z","pmid":"36787751","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}