{"doi":"10.1016/j.neuron.2020.06.010","title":"Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis","abstract":"A major obstacle to treating Alzheimer's disease (AD) is our lack of understanding of the molecular mechanisms underlying selective neuronal vulnerability, a key characteristic of the disease. Here, we present a framework integrating high-quality neuron-type-specific molecular profiles across the lifetime of the healthy mouse, which we generated using bacTRAP, with postmortem human functional genomics and quantitative genetics data. We demonstrate human-mouse conservation of cellular taxonomy at the molecular level for neurons vulnerable and resistant in AD, identify specific genes and pathways associated with AD neuropathology, and pinpoint a specific functional gene module underlying selective vulnerability, enriched in processes associated with axonal remodeling, and affected by amyloid accumulation and aging. We have made all cell-type-specific profiles and functional networks available at http://alz.princeton.edu. Overall, our study provides a molecular framework for understanding the complex interplay between Aβ, aging, and neurodegeneration within the most vulnerable neurons in AD.","journal":"Neuron","year":2020,"id":50496,"datarank":3.9538377274529326,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"self_citation_contribution":0.7886243058041673,"citation_network_contribution":3.1652134216487653,"self_endowment_contribution":0.7886243058041673,"citer_contribution":3.1652134216487653,"corpus_percentile":null,"corpus_rank":null,"citation_count":191,"citer_count":167,"citers_with_citation_signal":131,"citers_with_endowment":131,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7906,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245571,"name":"Vicky Yao","orcid":"0000-0002-3201-9983","position":1,"is_corresponding":false},{"id":249022,"name":"Patricia Rodriguez‐Rodriguez","orcid":"0000-0002-2438-3515","position":2,"is_corresponding":false},{"id":249023,"name":"Rose Oughtred","orcid":"0000-0002-6475-3373","position":3,"is_corresponding":false},{"id":105032,"name":"Jennifer Rust","orcid":null,"position":4,"is_corresponding":false},{"id":252520,"name":"Zakary Plautz","orcid":null,"position":5,"is_corresponding":false},{"id":249024,"name":"Shirin Kasturia","orcid":"0000-0002-1409-2423","position":6,"is_corresponding":false},{"id":249025,"name":"Christian A. Albornoz","orcid":"0000-0003-1062-0820","position":7,"is_corresponding":false},{"id":249026,"name":"Wei Wang","orcid":"0000-0002-3216-7118","position":8,"is_corresponding":false},{"id":249027,"name":"Eric F. Schmidt","orcid":"0000-0002-7869-0270","position":9,"is_corresponding":false},{"id":18923,"name":"Ruth Dannenfelser","orcid":"0000-0002-8766-6424","position":10,"is_corresponding":false},{"id":96850,"name":"Alicja Tadych","orcid":"0000-0001-8645-0739","position":11,"is_corresponding":false},{"id":249028,"name":"Lars Brichta","orcid":"0000-0001-9103-609X","position":12,"is_corresponding":false},{"id":249029,"name":"Alona O. Barnea-Cramer","orcid":"0000-0002-7604-0346","position":13,"is_corresponding":false},{"id":236878,"name":"Nathaniel Heintz","orcid":"0000-0002-8874-8704","position":14,"is_corresponding":false},{"id":38377,"name":"Patrick R. Hof","orcid":"0000-0002-3208-1154","position":15,"is_corresponding":false},{"id":5482,"name":"Myriam Heiman","orcid":"0000-0002-6365-8673","position":16,"is_corresponding":false},{"id":34971,"name":"Kara Dolinski","orcid":"0000-0002-7010-0264","position":17,"is_corresponding":false},{"id":249030,"name":"Marc Flajolet","orcid":"0000-0002-0518-7666","position":18,"is_corresponding":false},{"id":5951,"name":"Olga G. Troyanskaya","orcid":"0000-0002-5676-5737","position":19,"is_corresponding":false},{"id":230265,"name":"Paul Greengard","orcid":"0000-0002-4437-0893","position":20,"is_corresponding":false},{"id":249021,"name":"Jean-Pierre Roussarie","orcid":"0000-0003-2644-6046","position":0,"is_corresponding":true}],"reference_count":125,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:39:29.006085Z","pmid":"32603655","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}