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Our laser multiplexing approach is simple and fast, and could be used as a general method to image the activity of neural circuits in three dimensions across multiple areas in the brain.","is_dataset_classified":null,"base_score":5.5254529391317835,"endowment":5.5254529391317835,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26774159","pmcid":"PMC4724224","openalex_id":"https://openalex.org/W2228707969","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01MH100561","title":null},{"funder_name":"NCCDPHP CDC HHS","grant_id":"DP1EY024503","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01MH101218","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R41 MH100895","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01EY011787","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01MH101218-02","title":"Two-photon optical control of astrocytic function"},{"funder_name":"National Institutes of Health","grant_id":"5R41MH100895-02","title":"A novel 3D microscope for imaging and photostimulation"},{"funder_name":"National Institutes of Health","grant_id":"4R01MH100561-04","title":"Functional consequences of GABAergic inhibition of dendritic spines at puberty"},{"funder_name":"National Institutes of Health","grant_id":"4DP1EY024503-04","title":"Functional connectomics of the neocortical microcircuit"},{"funder_name":"National Institutes of Health","grant_id":"5R01EY011787-06","title":"Imaging Functional Connectivity in Visual Cortex"}],"total_grants":10,"fwci":52.4956,"citation_percentile":0.99860972,"influential_citations":0,"citation_trend":[{"year":2016,"count":21},{"year":2017,"count":28},{"year":2018,"count":32},{"year":2019,"count":40},{"year":2020,"count":22},{"year":2021,"count":31},{"year":2022,"count":21},{"year":2023,"count":19},{"year":2024,"count":16},{"year":2025,"count":10},{"year":2026,"count":9}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0896627315010855/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0896627315010855/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627315010855?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627315010855?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuron.2015.12.012","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26774159","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4724224","host_type":"repository"},{"url":"https://escholarship.org/uc/item/5hf7h45d","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.neuron.2015.12.012","host_type":""},{"url":"https://dx.doi.org/10.1016/j.neuron.2015.12.012","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.neuron.2015.12.012","host_type":""}],"fields_of_study":["Advanced Fluorescence Microscopy Techniques","Neural dynamics and brain function","Cell Image Analysis Techniques","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Calcium","Cerebral Cortex","Mice","Mice, Inbred C57BL","Microscopy, Fluorescence, Multiphoton","Nerve Net","Neurons"],"mesh_terms":["Animals","Calcium","Cerebral Cortex","Mice, Inbred C57BL","Nerve Net","Neurons","Microscopy, Fluorescence, Multiphoton","Mice"],"keywords":["Biological neural network","Calcium imaging","Non-negative matrix factorization","Premovement neuronal activity","Computer science","Multiplexing","Neuronal circuits","Neuroscience","Artificial neural network","Neural activity","Simple (philosophy)","Holography","Electronic circuit","Artificial intelligence","Matrix decomposition","Physics","Optics","Psychology","Chemistry","Calcium","1.1 Normal biological development and functioning","Neuroscience(all)","Bioengineering","Inbred C57BL","Fluorescence","Mice","Underpinning research","Animals","Multiphoton","Cerebral Cortex","Neurons","Microscopy","Neurology & Neurosurgery","Biomedical and Clinical Sciences","Neurosciences","Mice, Inbred C57BL","Microscopy, Fluorescence, Multiphoton","Neurological","Biological psychology","Cognitive Sciences","Nerve Net"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:14:01.788361Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}