{"doi":"10.1016/j.neuron.2005.08.026","title":"A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins","abstract":null,"journal":"Neuron","year":2005,"id":681491,"datarank":0.9248126781347132,"base_score":6.16541785423142,"endowment":6.16541785423142,"self_citation_contribution":0.9248126781347132,"citation_network_contribution":0.0,"self_endowment_contribution":0.9248126781347132,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":475,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463818,"name":"Alexander A. Chubykin","orcid":"0000-0001-8224-9296","position":1,"is_corresponding":false},{"id":669390,"name":"Davide Comoletti","orcid":"0000-0003-2081-6376","position":2,"is_corresponding":false},{"id":50254,"name":"Palmer Taylor","orcid":"0000-0002-3081-131X","position":3,"is_corresponding":false},{"id":21542,"name":"Thomas C. Südhof","orcid":"0000-0003-3361-9275","position":4,"is_corresponding":false},{"id":1780538,"name":"Antony A. Boucard","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins","abstract":"Previous studies suggested that postsynaptic neuroligins form a trans-synaptic complex with presynaptic beta-neurexins, but not with presynaptic alpha-neurexins. Unexpectedly, we now find that neuroligins also bind alpha-neurexins and that alpha- and beta-neurexin binding by neuroligin 1 is regulated by alternative splicing of neuroligin 1 (at splice site B) and of neurexins (at splice site 4). In neuroligin 1, splice site B is a master switch that determines alpha-neurexin binding but leaves beta-neurexin binding largely unaffected, whereas alternative splicing of neurexins modulates neuroligin binding. Moreover, neuroligin 1 splice variants with distinct neurexin binding properties differentially regulate synaptogenesis: neuroligin 1 that binds only beta-neurexins potently stimulates synapse formation, whereas neuroligin 1 that binds to both alpha- and beta-neurexins more effectively promotes synapse expansion. These findings suggest that neuroligin binding to alpha- and beta-neurexins mediates trans-synaptic cell adhesion but has distinct effects on synapse formation, indicating that expression of different neuroligin and neurexin isoforms specifies a trans-synaptic signaling code.","is_dataset_classified":null,"base_score":6.16541785423142,"endowment":6.16541785423142,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16242404","pmcid":null,"openalex_id":"https://openalex.org/W1990122129","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R37 MH52804-08","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R37MH052804-06","title":"FUNCTION OF NEUREXINS"}],"total_grants":2,"fwci":9.8124,"citation_percentile":0.99336682,"influential_citations":0,"citation_trend":[{"year":2012,"count":23},{"year":2013,"count":22},{"year":2014,"count":25},{"year":2015,"count":25},{"year":2016,"count":23},{"year":2017,"count":16},{"year":2018,"count":11},{"year":2019,"count":16},{"year":2020,"count":24},{"year":2021,"count":32},{"year":2022,"count":14},{"year":2023,"count":16},{"year":2024,"count":12},{"year":2025,"count":17},{"year":2026,"count":12}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0896627305007014?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0896627305007014?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuron.2005.08.026","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16242404","host_type":"repository"},{"url":"http://www.cell.com/article/S0896627305007014/pdf","host_type":""},{"url":"http://dx.doi.org/10.1016/j.neuron.2005.08.026","host_type":""},{"url":"https://dx.doi.org/10.1016/j.neuron.2005.08.026","host_type":""}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Retinal Development and Disorders","Cellular transport and secretion","0301 basic medicine","0303 health sciences","03 medical and health sciences","Alternative Splicing","Animals","Animals, Newborn","Blotting, Western","Cell Adhesion","Cell Adhesion Molecules, Neuronal","Cells, Cultured","Chromatography, Affinity","Electrophoretic Mobility Shift Assay","Glycoproteins","Green Fluorescent Proteins","Hippocampus","Humans","Immunohistochemistry","Membrane Proteins","Microtubule-Associated Proteins","Mutagenesis","Nerve Tissue Proteins","Neurons","Neuropeptides","Protein Binding","Rats","Recombinant Proteins","Synapses","Synapsins","Transfection"],"mesh_terms":["Animals","Animals, Newborn","Cell Adhesion","Cells, Cultured","Chromatography, Affinity","Glycoproteins","Hippocampus","Humans","Immunohistochemistry","Membrane Proteins","Microtubule-Associated Proteins","Nerve Tissue Proteins","Neurons","Neuropeptides","Protein Binding","Recombinant Proteins","Synapses","Transfection","Blotting, Western","Cell Adhesion Molecules, Neuronal","Mutagenesis","Synapsins","Alternative Splicing","Electrophoretic Mobility Shift Assay","Green Fluorescent Proteins","Rats"],"keywords":["Neuroligin","Neurexin","Synaptogenesis","Biology","Synapse","Cell biology","Postsynaptic potential","Alternative splicing","Gene isoform","Neuroscience","Biochemistry","Receptor","Gene","Neurons","Neuroscience(all)","Cell Adhesion Molecules, Neuronal","Blotting, Western","Green Fluorescent Proteins","Neuropeptides","Membrane Proteins","Electrophoretic Mobility Shift Assay","Nerve Tissue Proteins","Hippocampus","Immunohistochemistry","Chromatography, Affinity","Animals, Newborn","Mutagenesis","Cell Adhesion","Animals","Humans","Microtubule-Associated Proteins","Cells, Cultured","Glycoproteins"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T17:57:17.407768Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}