{"doi":"10.1016/j.neuron.2004.08.011","title":"Neuronal Synchrony Mediated by Astrocytic Glutamate through Activation of Extrasynaptic NMDA Receptors","abstract":null,"journal":"Neuron","year":2004,"id":673944,"datarank":1.0320576123279008,"base_score":6.880384082186005,"endowment":6.880384082186005,"self_citation_contribution":1.0320576123279008,"citation_network_contribution":0.0,"self_endowment_contribution":1.0320576123279008,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":972,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1729413,"name":"Olivier Pascual","orcid":null,"position":1,"is_corresponding":false},{"id":1760843,"name":"Sara Gobbo","orcid":null,"position":2,"is_corresponding":false},{"id":1760845,"name":"Tullio Pozzan","orcid":null,"position":3,"is_corresponding":false},{"id":233474,"name":"Philip G. 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Similar slow events also occur spontaneously, can still be observed when neuronal activity and synaptic glutamate release are blocked, and are found to be mediated by glutamate released from astrocytes acting preferentially on extrasynaptic NMDA receptors. The slow currents can be triggered by stimuli that evoke Ca2+ oscillations in astrocytes, including photolysis of caged Ca2+ in single astrocytes. As revealed by paired recording and Ca2+ imaging, a striking feature of this NMDA receptor response is that it occurs synchronously in multiple CA1 neurons. Our results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors.","is_dataset_classified":null,"base_score":6.880384082186005,"endowment":6.880384082186005,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15339653","pmcid":null,"openalex_id":"https://openalex.org/W2104417933","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"P20-MH-071705","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R37 NS37585","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS43142","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P20MH071705-02","title":"Project: The Regulation of Protein Synthesis"},{"funder_name":"National Institutes of Health","grant_id":"5R37NS037585-09","title":"Astrocyte-Neuron 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