{"doi":"10.1016/j.neuroimage.2022.119320","title":"Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region","abstract":"The subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by functional connectivity between local field potential recordings and simultaneous magnetoencephalography. Using a novel data set of 21 PD patients, we replicated previously reported cortico-STN coherence networks in the theta/alpha and beta frequency ranges, and looked for the spatial distribution of these networks within the STN region. Although theta/alpha and beta coherence peaks were both observed in on-medication recordings from electrode contacts at several locations within and around the STN, sites with theta/alpha coherence peaks were situated at significantly more inferior MNI coordinates than beta coherence peaks. Sites with only theta/alpha coherence peaks, i.e. without distinct beta coherence, were mostly located near the border of sensorimotor and cognitive/associative subregions as defined by a tractography-based atlas of the STN. Peak coherence values were largely unaltered by the medication state of the subject, however, theta/alpha peaks were more often identified in recordings obtained after administration of dopaminergic medication. Our findings suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, albeit with considerable spatial overlap between functional networks. Consequently, optimization of deep brain stimulation targeting might remain a trade-off between alleviating motor symptoms and avoiding adverse neuropsychiatric side effects.","journal":"NeuroImage","year":2022,"id":247010,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":319564,"name":"Wolf‐Julian Neumann","orcid":null,"position":1,"is_corresponding":false},{"id":884363,"name":"Daniel Kroneberg","orcid":"0000-0001-5560-538X","position":2,"is_corresponding":false},{"id":232911,"name":"Andreas Horn","orcid":"0000-0002-0695-6025","position":3,"is_corresponding":false},{"id":884364,"name":"Friederike Irmen","orcid":"0000-0001-5574-3790","position":4,"is_corresponding":false},{"id":884365,"name":"Tilmann Sander","orcid":"0000-0003-2984-5579","position":5,"is_corresponding":false},{"id":555644,"name":"Qiang Wang","orcid":"0000-0002-7604-8153","position":6,"is_corresponding":false},{"id":337265,"name":"Vladimir Litvak","orcid":"0000-0001-8535-7452","position":7,"is_corresponding":false},{"id":232910,"name":"Andrea A. Kühn","orcid":"0000-0002-4134-9060","position":8,"is_corresponding":false},{"id":884362,"name":"Bernadette C.M. van Wijk","orcid":"0000-0002-6129-0801","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35580809","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}