{"doi":"10.1016/j.neurobiolaging.2024.10.005","title":"Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease","abstract":"The hAβ-KI and APP SAA -KI are two amyloid models that harbor mutations in the endogenous mouse App gene. Both hAβ-KI and APP SAA -KI mice contain a humanized Aβ sequence, and APP SAA -KI mice carry three additional familial AD mutations. We herein report that the Aβ levels and Aβ42/Aβ40 ratio in APP SAA -KI homozygotes are dramatically higher than those in hAβ-KI homozygotes at 14 months of age. In addition, APP SAA -KI mice display a widespread distribution of amyloid plaques in the brain, whereas the plaques are undetectable in hAβ-KI mice. Moreover, there are no sex differences in amyloid pathology in APP SAA -KI mice. Both APP SAA -KI and hAβ-KI mice exhibit cognitive impairments, wherein no significant differences are found between these two models, although APP SAA KI mice show a trend towards worse cognitive function. Notably, female hAβ-KI and APP SAA -KI mice have a more pronounced cognitive impairments compared to their respective males. Our findings suggest that Aβ humanization contributes to cognitive deficits in APP SAA -KI mice, and that amyloid deposition might not be closely associated with cognitive impairments in APP SAA -KI mice.","journal":"Neurobiology of Aging","year":2024,"id":445774,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9286,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230886,"name":"Francis Shue","orcid":"0000-0003-1659-1952","position":1,"is_corresponding":false},{"id":257073,"name":"Aishe Kurti","orcid":null,"position":2,"is_corresponding":false},{"id":853311,"name":"Suren Jeevaratnam","orcid":"0000-0001-7556-6613","position":3,"is_corresponding":false},{"id":880045,"name":"Jesse R. Macyczko","orcid":"0000-0003-2847-8017","position":4,"is_corresponding":false},{"id":270895,"name":"Bhaskar Roy","orcid":"0000-0003-3604-6310","position":5,"is_corresponding":false},{"id":1262592,"name":"Taha Izhar","orcid":null,"position":6,"is_corresponding":false},{"id":494296,"name":"Ni Wang","orcid":"0000-0003-4961-7477","position":7,"is_corresponding":false},{"id":230893,"name":"Guojun Bu","orcid":"0000-0003-3491-1016","position":8,"is_corresponding":false},{"id":230892,"name":"Takahisa Kanekiyo","orcid":"0000-0001-6751-9374","position":9,"is_corresponding":false},{"id":848245,"name":"Yonghe Li","orcid":"0000-0003-3489-6362","position":10,"is_corresponding":false},{"id":234081,"name":"Wenyan Lü","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:01:46.243344Z","pmid":"39447490","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}