{"doi":"10.1016/j.neurobiolaging.2021.02.024","title":"CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia","abstract":"Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after >5 years. While sTREM2 is not a promising diagnostic biomarker for FTD-GRN or FTD-C9orf72, further research might elucidate its potential to monitor microglial activity and predict disease progression.","journal":"Neurobiology of Aging","year":2021,"id":187689,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263290,"name":"Estrella Morenas‐Rodríguez","orcid":"0000-0002-7591-6051","position":1,"is_corresponding":false},{"id":227422,"name":"Corey T. McMillan","orcid":"0000-0002-7581-6405","position":2,"is_corresponding":false},{"id":58510,"name":"Murray Grossman","orcid":"0000-0002-7447-6218","position":3,"is_corresponding":false},{"id":227417,"name":"David J. Irwin","orcid":"0000-0002-5599-5098","position":4,"is_corresponding":false},{"id":65662,"name":"Raquel Sánchez‐Valle","orcid":"0000-0001-7750-896X","position":5,"is_corresponding":false},{"id":65581,"name":"Caroline Graff","orcid":"0000-0002-9949-2951","position":6,"is_corresponding":false},{"id":65635,"name":"Rik Vandenberghe","orcid":"0000-0001-6237-2502","position":7,"is_corresponding":false},{"id":233807,"name":"Yolande A.L. Pijnenburg","orcid":"0000-0003-2464-1905","position":8,"is_corresponding":false},{"id":233776,"name":"Robert Laforce","orcid":"0000-0002-2031-490X","position":9,"is_corresponding":false},{"id":65598,"name":"Isabelle Le Ber","orcid":"0000-0002-2508-5181","position":10,"is_corresponding":false},{"id":27613,"name":"Alberto Lleó","orcid":"0000-0002-2568-5478","position":11,"is_corresponding":false},{"id":84331,"name":"Christian Haass","orcid":"0000-0002-4869-1627","position":12,"is_corresponding":false},{"id":241108,"name":"Marc Suárez‐Calvet","orcid":"0000-0002-2993-569X","position":13,"is_corresponding":false},{"id":233804,"name":"John C. van Swieten","orcid":"0000-0001-6278-6844","position":14,"is_corresponding":false},{"id":233781,"name":"Harro Seelaar","orcid":"0000-0003-1989-7527","position":15,"is_corresponding":false},{"id":615654,"name":"Emma L. van der Ende","orcid":"0000-0003-2570-8796","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:48:55.420619Z","pmid":"33896652","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}