{"doi":"10.1016/j.neurobiolaging.2021.01.010","title":"Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice","abstract":"The pathogenesis of Parkinson's disease involves fibrillization and deposition of alpha-synuclein (α-syn) into Lewy bodies. Accumulating evidence suggests that α-syn oligomers are particularly neurotoxic. Transgenic (tg) mice overexpressing wild-type human α-syn under the Thy-1 promoter (L61) reproduce many Parkinson's disease features, but the pathogenetic relevance of α-syn oligomers in this mouse model has not been studied in detail. Here, we report an age progressive increase of α-syn oligomers in the brain of L61 tg mice. Interestingly, more profound motor symptoms were observed in animals with higher levels of membrane-bound oligomers. As this tg model is X-linked, we also performed subset analyses, indicating that both sexes display a similar age-related increase in α-syn oligomers. However, compared with females, males featured increased brain levels of oligomers from an earlier age, in addition to a more severe behavioral phenotype with hyperactivity and thigmotaxis in the open field test. Taken together, our data indicate that α-syn oligomers are central to the development of brain pathology and behavioral deficits in the L61 tg α-syn mouse model.","journal":"Neurobiology of Aging","year":2021,"id":173117,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":710184,"name":"Agata Aniszewska","orcid":"0000-0001-9686-3967","position":1,"is_corresponding":false},{"id":710895,"name":"Astrid Gumucio","orcid":null,"position":2,"is_corresponding":false},{"id":58514,"name":"Eliezer Masliah","orcid":"0000-0002-2117-5569","position":3,"is_corresponding":false},{"id":710185,"name":"Anna Erlandsson","orcid":"0000-0001-7292-1608","position":4,"is_corresponding":false},{"id":710186,"name":"Joakim Bergström","orcid":"0000-0002-9700-5419","position":5,"is_corresponding":false},{"id":695188,"name":"Martin Ingelsson","orcid":"0000-0001-5466-8370","position":6,"is_corresponding":false},{"id":710187,"name":"Sara Ekmark‐Lewén","orcid":"0000-0003-2363-0593","position":7,"is_corresponding":false},{"id":710183,"name":"Sahar Roshanbin","orcid":"0000-0003-0339-831X","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:45.768135Z","pmid":"33639338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}