{"doi":"10.1016/j.neurobiolaging.2013.11.026","title":"Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice","abstract":null,"journal":"Neurobiology of Aging","year":2014,"id":588846,"datarank":3.7799907014156044,"base_score":4.61512051684126,"endowment":4.61512051684126,"self_citation_contribution":0.692268077526189,"citation_network_contribution":3.0877226238894155,"self_endowment_contribution":0.692268077526189,"citer_contribution":3.0877226238894155,"corpus_percentile":null,"corpus_rank":null,"citation_count":100,"citer_count":74,"citers_with_citation_signal":72,"citers_with_endowment":72,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":670040,"name":"Jin-Tai Yu","orcid":null,"position":1,"is_corresponding":false},{"id":1506562,"name":"Xi-Chen Zhu","orcid":null,"position":2,"is_corresponding":false},{"id":1506563,"name":"Meng-Shan Tan","orcid":null,"position":3,"is_corresponding":false},{"id":1506564,"name":"Li-Ze Gu","orcid":null,"position":4,"is_corresponding":false},{"id":1506565,"name":"Ying-Dong Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":291633,"name":"Lan Tan","orcid":"0000-0002-8759-7588","position":6,"is_corresponding":false},{"id":442050,"name":"Teng Jiang","orcid":"0000-0002-4204-6563","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice","abstract":"As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues via modulating the release of inflammatory cytokines. However, the role of TREM2 in aging-related neuroinflammation, cognitive deficiency, and AD-like neuropathology is unclear so far. Here, we detected the protein levels of TREM2 in brain of 3-, 7-, and 11-month-old senescence-accelerated mouse prone 8 (SAMP8) mice and observed that TREM2 levels were increased during aging process. We then knocked down TREM2 expression in brain of SAMP8 mice by nonviral RNA interference and found a significant increase in proinflammatory cytokines including tumor necrosis factor-α and interleukin (IL)-6, which was accompanied by a reduction in IL-10. Meanwhile, more obvious neuronal and synaptic losses and cognitive impairment were observed. These findings indicate that TREM2 may play a protective role against aging-related neuroinflammation and cognitive impairment.","is_dataset_classified":null,"base_score":4.61512051684126,"endowment":4.61512051684126,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24368090","pmcid":null,"openalex_id":"https://openalex.org/W2068527344","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81171209","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81371406","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81000544","title":null},{"funder_name":"Shandong Provincial Natural Science Foundation","grant_id":"ZR2011HZ001","title":null},{"funder_name":"Shandong Provincial Natural Science Foundation","grant_id":"ZR2010HQ004","title":null},{"funder_name":"Medicine and Health Science Technology Development Project of Shandong Province","grant_id":"2011WSA02018","title":null},{"funder_name":"Medicine and Health Science Technology Development Project of Shandong Province","grant_id":"2011WSA02020","title":null},{"funder_name":"Innovation Project for Postgraduates of Jiangsu Province","grant_id":"","title":null}],"total_grants":8,"fwci":5.9747,"citation_percentile":0.96204584,"influential_citations":0,"citation_trend":[{"year":2014,"count":10},{"year":2015,"count":11},{"year":2016,"count":9},{"year":2017,"count":4},{"year":2018,"count":9},{"year":2019,"count":8},{"year":2020,"count":5},{"year":2021,"count":12},{"year":2022,"count":13},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0197458013006106?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0197458013006106?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neurobiolaging.2013.11.026","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24368090","host_type":"repository"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Inflammation biomarkers and pathways","Neurological Disease Mechanisms and Treatments","Aging","Alzheimer Disease","Animals","Brain","Cognition Disorders","Cytokines","Disease Progression","Down-Regulation","Gene Knockdown Techniques","Inflammation Mediators","Interleukin-10","Interleukin-6","Male","Membrane Glycoproteins","Mice","Mice, Neurologic Mutants","Neurons","RNA, Small Interfering","Receptors, Immunologic","Synapses","Tumor Necrosis Factor-alpha"],"mesh_terms":["Aging","Alzheimer Disease","Animals","Brain","Cognition Disorders","Male","Membrane Glycoproteins","Mice, Neurologic Mutants","Neurons","Receptors, Immunologic","Synapses","Tumor Necrosis Factor-alpha","Down-Regulation","Interleukin-6","Cytokines","Interleukin-10","Disease Progression","Inflammation Mediators","RNA, Small Interfering","Mice","Gene Knockdown Techniques"],"keywords":["Neuroinflammation","TREM2","Proinflammatory cytokine","Senescence","Microglia","Inflammation","Tumor necrosis factor alpha","Receptor","Cognitive decline","Immunology","Biology","Medicine","Cell biology","Internal medicine","Dementia","Disease","Aging","Alzheimer's disease","Samp8","Samr1","Cognitive Deficiency"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.19136048","title":"Additional file 3 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19136048.v1","title":"Additional file 3 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19136045.v1","title":"Additional file 2 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19136045","title":"Additional file 2 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19136042.v1","title":"Additional file 1 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19136042","title":"Additional file 1 of Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway","publisher":"figshare","resource_type":"Image"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-22T22:50:48.796355Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}