{"doi":"10.1016/j.neurobiolaging.2013.05.017","title":"Striatal shape in Parkinson's disease","abstract":null,"journal":"Neurobiology of Aging","year":2013,"id":605609,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":268530,"name":"Guangwei Du","orcid":"0000-0002-8267-0301","position":1,"is_corresponding":false},{"id":268526,"name":"Mechelle M. Lewis","orcid":"0000-0002-1375-689X","position":2,"is_corresponding":false},{"id":1554299,"name":"Christopher Dimaio","orcid":null,"position":3,"is_corresponding":false},{"id":941841,"name":"Lan Kong","orcid":"0000-0001-8081-6322","position":4,"is_corresponding":false},{"id":592154,"name":"Paul J. Eslinger","orcid":"0000-0002-6032-7801","position":5,"is_corresponding":false},{"id":266786,"name":"Martin Styner","orcid":"0000-0002-8747-5118","position":6,"is_corresponding":false},{"id":268532,"name":"Xuemei Huang","orcid":"0000-0003-3583-5502","position":7,"is_corresponding":false},{"id":592153,"name":"Nicholas W. Sterling","orcid":"0000-0001-6240-0892","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Striatal shape in Parkinson's disease","abstract":"Parkinson's disease (PD) is marked pathologically by nigrostriatal dopaminergic terminal loss. Histopathological and in vivo labeling studies demonstrate that this loss occurs most extensively in the caudal putamen and caudate head. Previous structural studies have suggested reduced striatal volume and atrophy of the caudate head in PD subjects. The spatial distribution of atrophy in the putamen, however, has not been characterized. We aimed to delineate the specific locations of atrophy in both of these striatal structures. T1- and T2-weighted brain MR (3T) images were obtained from 40 PD and 40 control subjects having no dementia and similar age and gender distributions. Shape analysis was performed using doubly segmented regions of interest. Compared to controls, PD subjects had lower putamen (p = 0.0003) and caudate (p = 0.0003) volumes. Surface contraction magnitudes were greatest on the caudal putamen (p ≤ 0.005) and head and dorsal body of the caudate (p ≤ 0.005). This spatial distribution of striatal atrophy is consistent with the known pattern of dopamine depletion in PD and may reflect global consequences of known cellular remodeling phenomena.","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23820588","pmcid":"PMC3742686","openalex_id":"https://openalex.org/W2162597789","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"NS060722","title":null},{"funder_name":"National Institutes of Health","grant_id":"TL1 TR000125","title":null},{"funder_name":"National Institutes of Health","grant_id":"C06 RR016499","title":null},{"funder_name":"National Institutes of Health","grant_id":"UL1 TR000127","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"U01 NS082151","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"NIH UL1 TR000127","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS060722","title":null}],"total_grants":7,"fwci":3.5017,"citation_percentile":0.9296171,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":10},{"year":2017,"count":7},{"year":2018,"count":7},{"year":2019,"count":6},{"year":2020,"count":7},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742686","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742686","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0197458013002273?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0197458013002273?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neurobiolaging.2013.05.017","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23820588","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","Neurological disorders and treatments","Botulinum Toxin and Related Neurological Disorders","Aged","Brain Mapping","Cognition Disorders","Corpus Striatum","Female","Humans","Image Processing, Computer-Assisted","Magnetic Resonance Imaging","Male","Middle Aged","Multivariate Analysis","Neuropsychological Tests","Parkinson Disease","Statistics as Topic"],"mesh_terms":["Aged","Brain Mapping","Cognition Disorders","Corpus Striatum","Female","Humans","Image Processing, Computer-Assisted","Magnetic Resonance Imaging","Male","Middle Aged","Neuropsychological Tests","Parkinson Disease","Statistics as Topic","Multivariate Analysis"],"keywords":["Putamen","Atrophy","Caudate nucleus","Dopaminergic","Parkinson's disease","Neuroscience","Medicine","Pathology","Internal medicine","Dopamine","Psychology","Disease","Structure","Morphology","Volume","Striatum","Shape","Magnetic resonance imaging (MRI)","Caudate"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T02:50:02.112423Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}