{"doi":"10.1016/j.neurobiolaging.2009.06.007","title":"Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation","abstract":null,"journal":"Neurobiology of Aging","year":2011,"id":660171,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1723362,"name":"T. 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Brandt","orcid":null,"position":12,"is_corresponding":false},{"id":1723361,"name":"M. Hundelt","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation","abstract":"The role of hyperphosphorylation of tau in Alzheimer's disease is still unsolved. Here we describe a novel transgenic mouse model, expressing a pseudohyperphosphorylated (PHP) variant of the longest human CNS tau isoform in forebrain neurons. We report that pseudohyperphosphorylation decreases phosphorylation at T205 while other sites (T212, S262) are less or not affected compared to mice expressing wildtype tau. Despite the differences in phosphorylation, the subcellular distribution of tau is not affected and mice do not develop highly aggregated states of tau. PHP tau expressing mice do not show any evidence for neurodegeneration as determined from morphometric measurements of neocortical regions, caspase activation, analysis of mitochondrial dysfunction, or determination of spine densities. In agreement, no differences in learning and memory are observed. The data indicates that moderate levels of modified tau alone are not sufficient to induce tau aggregation or neurodegeneration in transgenic mice. With our model it becomes possible to study the effects of hyperphosphorylation at conditions which may prevail in an early preaggregation state of the disease.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19660835","pmcid":null,"openalex_id":"https://openalex.org/W2071580328","authors":[],"funders":[],"total_grants":0,"fwci":1.4158,"citation_percentile":0.80926854,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0197458009002115?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0197458009002115?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neurobiolaging.2009.06.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19660835","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Neuroscience and Neuropharmacology Research","Mitochondrial Function and Pathology","Age Factors","Animals","Disease Models, Animal","Female","Humans","Male","Mice","Mice, Inbred C57BL","Mice, Transgenic","Minisatellite Repeats","Nerve Degeneration","Neurons","Phosphorylation","Prosencephalon","Protein Binding","Silver Staining","Sulfate Adenylyltransferase","tau Proteins"],"mesh_terms":["Age Factors","Animals","Disease Models, Animal","Female","Humans","Male","Mice, Inbred C57BL","Mice, Transgenic","Nerve Degeneration","Neurons","Phosphorylation","Protein Binding","Sulfate Adenylyltransferase","Prosencephalon","Silver Staining","tau Proteins","Minisatellite Repeats","Mice"],"keywords":["Neurodegeneration","Hyperphosphorylation","Phosphorylation","Genetically modified mouse","Gene isoform","Tauopathy","Cyclin-dependent kinase 5","Transgene","Neuroscience","Forebrain","Tau protein","Biology","Cell biology","Alzheimer's disease","Disease","Internal medicine","Medicine","Biochemistry","Central nervous system","Protein kinase A","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T08:36:50.607236Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}