{"doi":"10.1016/j.neuro.2012.06.008","title":"Integration of genome-wide expression and methylation data: Relevance to aging and Alzheimer's disease","abstract":null,"journal":"NeuroToxicology","year":2012,"id":593291,"datarank":1.2336588929545846,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.7091827587346127,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.7091827587346127,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":24,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1518484,"name":"Remi Dosunmu","orcid":null,"position":1,"is_corresponding":false},{"id":1105538,"name":"Nasser H. Zawia","orcid":null,"position":2,"is_corresponding":false},{"id":514693,"name":"Hany Alashwal","orcid":"0000-0002-5721-5104","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Integration of genome-wide expression and methylation data: Relevance to aging and Alzheimer's disease","abstract":"The progressive and latent nature of neurodegenerative diseases, such as Alzheimer's disease (AD) indicates the role of epigenetic modification in disease susceptibility. Previous studies from our lab show that developmental exposure to lead (Pb) perturbs the expression of AD-associated proteins. In order to better understand the role of DNA methylation as an epigenetic modifications mechanism in gene expression regulation, an integrative study of global gene expression and methylation profiles is essential. Given the different formats of gene expression and methylation data, combining these data for integrative analysis can be challenging. In this paper we describe a method to integrate and analyze gene expression and methylation arrays. Methylation array raw data contain the signal intensities of each probe of CpG sites, whereas gene expression data measure the signal intensity values of genes. In order to combine these data, methylation data of CpG sites have to be associated with genes.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22743688","pmcid":"PMC3469774","openalex_id":"https://openalex.org/W2094569740","authors":[],"funders":[{"funder_name":"Intramural Research Program of the National Institutes of Health","grant_id":"ES013022","title":null},{"funder_name":"Intramural Research Program of the National Institutes of Health","grant_id":"AG027246","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R21 ES013022","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES015867","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R03 AG027246","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P20 RR016457","title":null},{"funder_name":"National Institutes of Health","grant_id":"2P20RR016457-04","title":"BRIN: URI: TMSR/CHEMICAL CARCINOGENESIS SUBCORE"},{"funder_name":"National Institutes of Health","grant_id":"5R21ES013022-03","title":"Fetal Pb-exposure and neurodegeneration in aging brains"},{"funder_name":"National Institutes of Health","grant_id":"1R03AG027246-01A2","title":"Neonatal exposure &neurodegeneration of the aged brain"},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null},{"funder_name":"National Institute of Environmental Health Sciences","grant_id":"","title":null},{"funder_name":"National Center for Research Resources","grant_id":"","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":13,"fwci":1.2274,"citation_percentile":0.78008745,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":4},{"year":2015,"count":2},{"year":2016,"count":8},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://digitalcommons.uri.edu/bps_facpubs/122","host_type":"repository"},{"url":"https://digitalcommons.uri.edu/bps_facpubs/122","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0161813X12001404?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0161813X12001404?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neuro.2012.06.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22743688","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3469774","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3469774?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1016/j.neuro.2012.06.008","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.neuro.2012.06.008","host_type":""}],"fields_of_study":["Epigenetics and DNA Methylation","Genetic Syndromes and Imprinting","Genomics and Chromatin Dynamics","0301 basic medicine","03 medical and health sciences","Aging","Alzheimer Disease","Animals","CpG Islands","DNA Methylation","Disease Models, Animal","Gene Expression Profiling","Gene Expression Regulation","Genetic Predisposition to Disease","Genome-Wide Association Study","Lead Poisoning, Nervous System","Male","Mice","Mice, Inbred C57BL","Oligonucleotide Array Sequence Analysis","Systems Biology","Systems Integration"],"mesh_terms":["Aging","Alzheimer Disease","Animals","Disease Models, Animal","Gene Expression Regulation","Male","Mice, Inbred C57BL","Systems Integration","CpG Islands","DNA Methylation","Genetic Predisposition to Disease","Lead Poisoning, Nervous System","Oligonucleotide Array Sequence Analysis","Gene Expression Profiling","Systems Biology","Mice","Genome-Wide Association Study"],"keywords":["Epigenetics","DNA methylation","Methylation","CpG site","Biology","Gene expression","Regulation of gene expression","Genetics","Gene","Computational biology","Male","570","Aging","Gene Expression Profiling","Systems Biology","610","Mice, Inbred C57BL","Systems Integration","Disease Models, Animal","Mice","Lead Poisoning, Nervous System","Gene Expression Regulation","Alzheimer Disease","Animals","CpG Islands","Genetic Predisposition to Disease","Genome-Wide Association Study","Oligonucleotide Array Sequence Analysis"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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