{"doi":"10.1016/j.neures.2026.105091","title":"Cellular and molecular networks governing myelination dynamics in the central nervous system","abstract":null,"journal":"Neuroscience Research","year":2026,"id":675399,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1764658,"name":"Manyue Ge","orcid":null,"position":1,"is_corresponding":false},{"id":1470024,"name":"Ting Li","orcid":"0009-0007-8797-2353","position":2,"is_corresponding":false},{"id":1764659,"name":"Zhenghao Li","orcid":null,"position":3,"is_corresponding":false},{"id":389125,"name":"Xiaoyu Shi","orcid":"0000-0003-3856-594X","position":4,"is_corresponding":false},{"id":1764660,"name":"Jingyi Guo","orcid":null,"position":5,"is_corresponding":false},{"id":1408244,"name":"Cheng He","orcid":"0000-0002-8470-0834","position":6,"is_corresponding":false},{"id":368550,"name":"Pengfei Yang","orcid":"0000-0002-6154-3602","position":7,"is_corresponding":false},{"id":515224,"name":"Qi Shao","orcid":"0000-0002-8190-1067","position":8,"is_corresponding":false},{"id":231779,"name":"Peng Liu","orcid":"0000-0001-6965-8001","position":9,"is_corresponding":false},{"id":809417,"name":"Yong Wang","orcid":"0000-0002-0821-6549","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cellular and molecular networks governing myelination dynamics in the central nervous system","abstract":"Myelin, a multilamellar membrane structure enwrapping axons, is essential for rapid saltatory conduction, metabolic support, and long-term axonal integrity in the central nervous system (CNS). Myelination by oligodendrocytes (OLs) constitutes a highly dynamic and orchestrated process, encompassing distinct stages: target axon recognition, axonal wrapping, membrane expansion, and compaction. This review comprehensively summarizes recent advances in understanding the dynamics of CNS myelination which is spatiotemporally regulated through a complex interplay of membrane protein interaction, neuronal activity, metabolic checkpoints, and mechanosensory mechanisms. We highlight how adhesive molecules, cytoskeletal dynamics, and polarized membrane trafficking collectively drive the precise spiraling of myelin around axons. Furthermore, we emphasize the indispensable non-cell autonomous roles of astrocytes and microglia, which contribute critically through lipid transfer, phagocytic refinement, and modulation of the extracellular matrix. Beyond development, we discuss mechanisms that sustain myelin homeostasis, such as autophagy-lysosomal clearance. By integrating these mechanistic insights, we not only underscore the exquisite precision of CNS myelination but also illuminate potential therapeutic targets for demyelinating disorders.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42468607","pmcid":null,"openalex_id":"https://openalex.org/W7169498564","authors":[],"funders":[{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.76816239,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0168010226000787/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0168010226000787/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168010226000787?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168010226000787?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neures.2026.105091","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42468607","host_type":"repository"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Neuroscience and Neuropharmacology Research","Nerve injury and regeneration"],"mesh_terms":["Animals","Axons","Central Nervous System","Humans","Myelin Sheath","Oligodendroglia"],"keywords":["Central nervous system","Dynamics (music)","Nervous system","Network dynamics","oligodendrocyte","Myelination","Neurodevelopmental Disorders","Cellular Dynamics","Axon-glia Interactions"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T23:53:52.441577Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}