{"doi":"10.1016/j.neulet.2016.09.054","title":"The African clawed frog Xenopus laevis : A model organism to study regeneration of the central nervous system","abstract":null,"journal":"Neuroscience Letters","year":2017,"id":590097,"datarank":1.593090476238903,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.9474807122582776,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.9474807122582776,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":56,"citers_with_citation_signal":46,"citers_with_endowment":46,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1509864,"name":"Emilio E. Méndez-Olivos","orcid":null,"position":1,"is_corresponding":false},{"id":1509865,"name":"Rosana Muñoz","orcid":null,"position":2,"is_corresponding":false},{"id":1509866,"name":"Juan Larraín","orcid":null,"position":3,"is_corresponding":false},{"id":1509863,"name":"Dasfne Lee-Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The African clawed frog Xenopus laevis : A model organism to study regeneration of the central nervous system","abstract":"While an injury to the central nervous system (CNS) in humans and mammals is irreversible, amphibians and teleost fish have the capacity to fully regenerate after severe injury to the CNS. Xenopus laevis has a high potential to regenerate the brain and spinal cord during larval stages (47-54), and loses this capacity during metamorphosis. The optic nerve has the capacity to regenerate throughout the frog's lifespan. Here, we review CNS regeneration in frogs, with a focus in X. laevis, but also provide some information about X. tropicalis and other frogs. We start with an overview of the anatomy of the Xenopus CNS, including the main supraspinal tracts that emerge from the brain stem, which play a key role in motor control and are highly conserved across vertebrates. We follow with the advantages of using Xenopus, a classical laboratory model organism, with increasing availability of genetic tools like transgenesis and genome editing, and genomic sequences for both X. laevis and X. tropicalis. Most importantly, Xenopus provides the possibility to perform intra-species comparative experiments between regenerative and non-regenerative stages that allow the identification of which factors are permissive for neural regeneration, and/or which are inhibitory. We aim to provide sufficient evidence supporting how useful Xenopus can be to obtain insights into our understanding of CNS regeneration, which, complemented with studies in mammalian vertebrate model systems, can provide a collaborative road towards finding novel therapeutic approaches for injuries to the CNS.","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27693567","pmcid":null,"openalex_id":"https://openalex.org/W2527259077","authors":[],"funders":[],"total_grants":0,"fwci":2.6273,"citation_percentile":0.89389909,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":8},{"year":2020,"count":9},{"year":2021,"count":15},{"year":2022,"count":9},{"year":2023,"count":8},{"year":2024,"count":9},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304394016307376?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304394016307376?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neulet.2016.09.054","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27693567","host_type":"repository"}],"fields_of_study":["Nerve injury and regeneration","Neurogenesis and neuroplasticity mechanisms","Signaling Pathways in Disease"],"mesh_terms":["Gene Editing","Animals","Brain","Brain Injuries","Central Nervous System","Larva","Metamorphosis, Biological","Nerve Regeneration","Optic Nerve","Spinal Cord","Spinal Cord Injuries","Xenopus laevis","Transgenes","Models, Animal"],"keywords":["Xenopus","African clawed frog","Biology","Model organism","Regeneration (biology)","Metamorphosis","Neuroscience","Vertebrate","Central nervous system","Nervous system","Amphibian","Zebrafish","Spinal cord","Anatomy","Evolutionary biology","Cell biology","Gene","Genetics","Larva","Ecology","Brain","optic nerve","Central Nervous System Regeneration","Regenerative Model Organisms"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.26570968.v1","title":"Additional file 1 of Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26570968","title":"Additional file 1 of Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T13:07:30.687744Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}