{"doi":"10.1016/j.neulet.2016.03.029","title":"Loss aversion is associated with bilateral insula volume. A voxel based morphometry study","abstract":null,"journal":"Neuroscience Letters","year":2016,"id":603857,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1549147,"name":"G. Heeren","orcid":null,"position":1,"is_corresponding":false},{"id":1549148,"name":"C. Montag","orcid":null,"position":2,"is_corresponding":false},{"id":1507446,"name":"B. Weber","orcid":null,"position":3,"is_corresponding":false},{"id":1549149,"name":"M. Reuter","orcid":null,"position":4,"is_corresponding":false},{"id":1549146,"name":"S. Markett","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Loss aversion is associated with bilateral insula volume. A voxel based morphometry study","abstract":"Loss aversion is a decision bias, reflecting a greater sensitivity to losses than to gains in a decision situation. Recent neuroscientific research has shown that mesocorticolimbic structures like ventromedial prefrontal cortex and the ventral striatum constitute a bidirectional neural system that processes gains and losses and exhibits a neural basis of loss aversion. On a functional and structural level, the amygdala and insula also seem to play an important role in the processing of loss averse behavior. By applying voxel-based morphometry to structural brain images in N=41 healthy participants, the current study provides further evidence for the relationship of brain structure and loss aversion. The results show a negative correlation of gray matter volume in bilateral posterior insula as well as left medial frontal gyrus with individual loss aversion. Hence, higher loss aversion is associated with lower gray matter volume in these brain areas. Both structures have been discussed to play important roles in the brain's salience network, where the posterior insula is involved in interoception and the detection of salience. The medial frontal gyrus might impact decision making through its dense connections with the anterior cingulate cortex. A possible explanation for the present finding is that structural differences in these regions alter the processing of losses and salience, possibly biasing decision making towards avoidance of negative outcomes.","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27012426","pmcid":null,"openalex_id":"https://openalex.org/W2306160283","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"German Research Foundation","grant_id":"","title":null}],"total_grants":2,"fwci":2.551,"citation_percentile":0.88945287,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":8},{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":7},{"year":2021,"count":8},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304394016301677?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304394016301677?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neulet.2016.03.029","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27012426","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.neulet.2016.03.029","host_type":""}],"fields_of_study":["Neural and Behavioral Psychology Studies","Visual perception and processing mechanisms","05 social sciences","03 medical and health sciences","0302 clinical medicine","0501 psychology and cognitive sciences","Adult","Amygdala","Anticipation, Psychological","Cerebral Cortex","Decision Making","Female","Gambling","Gray Matter","Humans","Magnetic Resonance Imaging","Male","Organ Size","Prefrontal Cortex","Young Adult"],"mesh_terms":["Adult","Amygdala","Cerebral Cortex","Decision Making","Female","Gambling","Humans","Magnetic Resonance Imaging","Male","Organ Size","Prefrontal Cortex","Young Adult","Anticipation, Psychological","Gray Matter"],"keywords":["Insula","Voxel-based morphometry","Voxel","Brain size","Loss aversion","Neuroscience","Psychology","Medicine","Magnetic resonance imaging","Radiology","Economics","White matter","Posterior Insula","Vbm","Salience Network","Adult","Cerebral Cortex","Male","Decision Making","Prefrontal Cortex","Organ Size","Amygdala","Anticipation, Psychological","Young Adult","Gambling","Humans","Female","Gray Matter"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. Zero hunger"},{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Peace, Justice and strong institutions"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:52:04.565297Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}