{"doi":"10.1016/j.neulet.2011.11.059","title":"Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats","abstract":null,"journal":"Neuroscience Letters","year":2012,"id":660672,"datarank":0.6064576901751826,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":0.0,"self_endowment_contribution":0.6064576901751826,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1724689,"name":"Basak Baykara","orcid":null,"position":1,"is_corresponding":false},{"id":1724692,"name":"Ilkay Aksu","orcid":null,"position":2,"is_corresponding":false},{"id":1724695,"name":"Muge Kiray","orcid":null,"position":3,"is_corresponding":false},{"id":1724699,"name":"Ali Riza Sisman","orcid":null,"position":4,"is_corresponding":false},{"id":1724702,"name":"Ferihan Cetin","orcid":null,"position":5,"is_corresponding":false},{"id":1724705,"name":"Ayfer Dayi","orcid":null,"position":6,"is_corresponding":false},{"id":1724708,"name":"Tugba Gurpinar","orcid":null,"position":7,"is_corresponding":false},{"id":1724710,"name":"Nazan Uysal","orcid":null,"position":8,"is_corresponding":false},{"id":1724713,"name":"M. Nuri Arda","orcid":null,"position":9,"is_corresponding":false},{"id":1724684,"name":"Durgul Ozdemir","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats","abstract":"It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22172933","pmcid":null,"openalex_id":"https://openalex.org/W2035035969","authors":[],"funders":[],"total_grants":0,"fwci":2.3109,"citation_percentile":0.88552158,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":11},{"year":2014,"count":2},{"year":2015,"count":8},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2025,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304394011015813?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304394011015813?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.neulet.2011.11.059","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22172933","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Anesthesia and Neurotoxicity Research","Traumatic Brain Injury and Neurovascular Disturbances","Animals","Brain Injuries","Cognition","Cognition Disorders","Hippocampus","Insulin-Like Growth Factor I","Rats","Rats, Wistar","Statistics as Topic"],"mesh_terms":["Animals","Brain Injuries","Cognition","Cognition Disorders","Hippocampus","Insulin-Like Growth Factor I","Statistics as Topic","Rats, Wistar","Rats"],"keywords":["Hippocampal formation","Cresyl violet","Morris water navigation task","Traumatic brain injury","Hippocampus","Brain damage","TUNEL assay","Medicine","Neuroscience","Psychology","Internal medicine","Endocrinology","Pathology","Staining","Immunohistochemistry","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T09:40:46.116012Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}