{"doi":"10.1016/j.neulet.2004.03.092","title":"Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons","abstract":null,"journal":"Neuroscience Letters","year":2004,"id":630422,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1633188,"name":"Jennifer Hoard","orcid":null,"position":1,"is_corresponding":false},{"id":1633190,"name":"G.Cristina Brailoiu","orcid":null,"position":2,"is_corresponding":false},{"id":1633192,"name":"Michelle Chi","orcid":null,"position":3,"is_corresponding":false},{"id":1633194,"name":"Ramona Godbolde","orcid":null,"position":4,"is_corresponding":false},{"id":1633196,"name":"Nae J Dun","orcid":null,"position":5,"is_corresponding":false},{"id":528237,"name":"Eugen Brailoiu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons","abstract":"The present study was undertaken to evaluate the effects of ultra low concentrations (10(-9) or 10(-14)M) of morphine on neurite elongation in cultured neurons dissociated from rat spinal cords and cerebral cortex. In fetal serum (FS) or fetal serum-free supplemented with cAMP media, the length of longest neurite was significantly increased by 10(-9) or 10(-14)M morphine. For example, 10(-14)M morphine increased neurite length by 24 +/- 0.5% and 27 +/- 0.3% in spinal cord neurons, and 18 +/- 0.2% and 17 +/- 0.6% in cortical neurons. Morphine (10(-6)M) had no significant effect on neurite length of spinal and cortical neurons. The relative frequency distribution of neurite length revealed 61 +/- 2.7% of spinal neurons and 48 +/- 2.6% of cortical neurons are responsive to ultra low concentrations of morphine. In the responsive populations, morphine (10(-14)M) enhanced the neurite outgrowth in spinal neurons by 58 +/- 0.9% and 48 +/- 1.2% and in cortical neurons by 31 +/- 0.6% and 28 +/- 0.9% in FS and cAMP-supplemented media, respectively. Pretreatment with naloxone did not prevent the morphine effect. The result shows that morphine at ultra low concentrations enhances neurite outgrowth of spinal and cortical neurons via a naloxone-independent mechanism.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15234463","pmcid":null,"openalex_id":"https://openalex.org/W15234463","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS18710","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS39646","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.00218627,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304394004005105?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304394004005105?httpAccept=text/plain","host_type":"publisher"},{"url":"https://www.osti.gov/scitech/biblio/6811453-assessment-voc-emissions-from-fiberglass-boat-manufacturing-final-report","host_type":"repository"}],"fields_of_study":["Vehicle emissions and performance","Odor and Emission Control Technologies","Animals","Animals, Newborn","Cells, Cultured","Cerebral Cortex","Dose-Response Relationship, Drug","Morphine","Naloxone","Narcotic Antagonists","Narcotics","Neurites","Rats","Spinal Cord"],"mesh_terms":["Cerebral Cortex","Spinal Cord","Neurites","Cells, Cultured","Animals","Animals, Newborn","Rats","Morphine","Naloxone","Narcotics","Narcotic Antagonists","Dose-Response Relationship, Drug"],"keywords":["Volatile organic compound","Environmental science","Waste management","Fugitive emissions","Lamination","Engineering","Environmental engineering","Greenhouse gas","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:14:24.593349Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}