{"doi":"10.1016/j.nbd.2023.106385","title":"Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation – A 5-year follow-up [11C]PIB-PET study","abstract":null,"journal":"Neurobiology of Disease","year":2024,"id":655433,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241107,"name":"Anniina Snellman","orcid":"0000-0001-6191-0954","position":1,"is_corresponding":false},{"id":1710997,"name":"Jouni Tuisku","orcid":null,"position":2,"is_corresponding":false},{"id":1710998,"name":"Semi Helin","orcid":null,"position":3,"is_corresponding":false},{"id":1543013,"name":"Matti Viitanen","orcid":null,"position":4,"is_corresponding":false},{"id":22044,"name":"Antti Jula","orcid":null,"position":5,"is_corresponding":false},{"id":258676,"name":"Juha O. Rinne","orcid":"0000-0001-6369-0764","position":6,"is_corresponding":false},{"id":692190,"name":"Laura L. Ekblad","orcid":"0000-0002-5863-8088","position":7,"is_corresponding":false},{"id":1710996,"name":"Elina Pietilä","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation – A 5-year follow-up [11C]PIB-PET study","abstract":"We studied if midlife insulin resistance (IR) and APOE genotype would predict brain beta-amyloid (Aβ) accumulation and Aβ change in late-life in 5-year follow-up [11C]PIB-PET study. 43 dementia-free participants were scanned twice with [11C]PIB-PET in their late-life (mean age at follow-up 75.4 years). Participants were recruited from the Finnish Health2000 study according to their HOMA-IR values measured in midlife (mean age at midlife 55.4 years; IR+ group, HOMA-IR > 2.17; IR- group, HOMA-IR <1.25), and their APOEε4 genotype. At late-life follow-up, [11C]PIB-PET composite SUVr was significantly higher in IR+ group than IR- group (median 2.3 (interquartile range 1.7-3.3) vs. 1.7 (1.5-2.4), p = 0.03). There was no difference between IR- and IR+ groups in [11C]PIB-PET SUVr 5-year change, but the change was significantly higher in IR+/APOEε4+ group (median change 0.8 (0.60-1.0)) than in IR-/APOEε4- (0.28 (0.14-0.47), p = 0.02) and in IR+/APOEε4- group (0.24 (0.06-0.40), p = 0.046). These results suggest that APOEε4 carriers with midlife IR are at increased risk for late-life Aβ accumulation.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38123104","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.nbd.2023.106385","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0969996123004011?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0969996123004011?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doaj.org/article/6e5db428506544d58bbdf60d855047ba","host_type":"repository"}],"fields_of_study":["Humans","Aged","Middle Aged","Follow-Up Studies","Insulin Resistance","Amyloid beta-Peptides","Brain","Genotype","Apolipoproteins E","Positron-Emission Tomography","Alzheimer Disease","Aniline Compounds"],"mesh_terms":["Humans","Aged","Middle Aged","Follow-Up Studies","Insulin Resistance","Amyloid beta-Peptides","Brain","Genotype","Apolipoproteins E","Positron-Emission Tomography","Alzheimer Disease","Aniline Compounds"],"keywords":["APOEe4","Alzheimer's disease","Beta-amyloid","HOMA-IR","Insulin resistance","[11C]PIB-PET"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T10:52:09.115454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}