{"doi":"10.1016/j.nbd.2022.105928","title":"Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy","abstract":null,"journal":"Neurobiology of Disease","year":2022,"id":653287,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1704532,"name":"Laurent Sheybani","orcid":null,"position":1,"is_corresponding":false},{"id":291122,"name":"Nitish Seenarine","orcid":"0000-0002-6844-675X","position":2,"is_corresponding":false},{"id":259361,"name":"Itzhak Fried","orcid":"0000-0002-5962-2678","position":3,"is_corresponding":false},{"id":240426,"name":"Chengyuan Wu","orcid":"0000-0002-3954-2929","position":4,"is_corresponding":false},{"id":240425,"name":"Ashwini Sharan","orcid":"0000-0002-4759-6097","position":5,"is_corresponding":false},{"id":153526,"name":"Jerome Engel","orcid":null,"position":6,"is_corresponding":false},{"id":227186,"name":"Michael R. Sperling","orcid":"0000-0003-0708-6006","position":7,"is_corresponding":false},{"id":197428,"name":"Yuval Nir","orcid":null,"position":8,"is_corresponding":false},{"id":581696,"name":"Richard J. Staba","orcid":"0000-0003-2285-5627","position":9,"is_corresponding":false},{"id":672596,"name":"Shennan A. Weiss","orcid":"0000-0003-0825-8439","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy","abstract":"Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple (FR, 200-600 Hz) are biomarkers of epileptogenic brain, and we postulated that FR network interactions are involved in generating epileptiform spikes. Using macroelectrode stereo intracranial EEG (iEEG) recordings from a cohort of 46 patients we found that, in the seizure onset zone (SOZ), propagating FR were more often followed by an epileptiform spike, as compared with non-propagating FR (p < 0.05). Propagating FR had a distinct frequency and larger power (p < 1e-10) and were more strongly phase coupled to the peak of iEEG delta oscillation, which likely correspond with the DOWN states during non-REM sleep (p < 1e-8), than non-propagating FR. While FR propagation was rare, all FR occurred with the highest probability within +/- 400 msec of epileptiform spikes with superimposed high-frequency oscillations (p < 0.05). Thus, a sub-population of epileptiform spikes in the SOZ, are preceded by propagating FR that are coordinated by the DOWN state during non-REM sleep.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36403895","pmcid":"PMC12323987","openalex_id":"https://openalex.org/W4309184626","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"864353","title":"Sleep and episodic memory consolidation:  ‘No-report’ paradigms, brain mechanisms, and dementia"},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS106957","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"K23 NS094633","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"RF1 NS033310","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS033310","title":null},{"funder_name":"Swiss National Science Foundation","grant_id":"206720","title":"Epileptogenesis across the sleep-wake cycle"},{"funder_name":"National Institutes of Health","grant_id":"5K23NS094633-02","title":"Reducing or obviating the need for chronic intracranial electroencephalogram telemetry for epilepsy surgery patients by utilizing inter-ictal HFO rates: A study of diagnostic accuracy"},{"funder_name":"Swiss National Science Foundation","grant_id":"33310","title":"Regulation of human fibronectin gene expression in response to glucocorticoids and oncogenes."},{"funder_name":"National Institutes of Health","grant_id":"5R01NS033310-07","title":"IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS"},{"funder_name":"NINDS","grant_id":"","title":null}],"total_grants":10,"fwci":2.4863,"citation_percentile":0.90241595,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":11},{"year":2024,"count":6},{"year":2025,"count":9},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.nbd.2022.105928","host_type":"journal"},{"url":"https://doi.org/10.1016/j.nbd.2022.105928","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0969996122003205?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0969996122003205?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36403895","host_type":"repository"},{"url":"https://doaj.org/article/e44df07a9205476ebaea11799e22278e","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12323987","host_type":"repository"},{"url":"https://doi.org/10.21203/rs.3.rs-1640013/v2","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/36403895/","host_type":""},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12323987/","host_type":""},{"url":"https://archive-ouverte.unige.ch/unige:172330","host_type":""},{"url":"http://dx.doi.org/10.1016/j.nbd.2022.105928","host_type":""}],"fields_of_study":["Photoreceptor and optogenetics research","Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Humans","Epilepsies, Partial","Electrocorticography","Brain Waves","Brain","Electroencephalography"],"mesh_terms":["Electrocorticography","Brain","Electroencephalography","Epilepsies, Partial","Humans","Brain Waves"],"keywords":["Epilepsy","Oscillation (cell signaling)","Neuroscience","Electroencephalography","Physics","Delta wave","Psychology","Medicine","Chemistry","Slow Wave Sleep","Fast Ripple","Focal Epilepsy","Epileptiform Discharge","Down State","High-frequency Oscillation","570","616.8","610","Neurosciences. 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