{"doi":"10.1016/j.nbd.2020.105064","title":"Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder","abstract":"Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD.","journal":"Neurobiology of Disease","year":2020,"id":96059,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":476735,"name":"Yu Tahara","orcid":"0000-0002-3015-8883","position":1,"is_corresponding":false},{"id":476736,"name":"Shu Hon Christopher Luk","orcid":"0000-0002-2757-7817","position":2,"is_corresponding":false},{"id":477947,"name":"Yoon-Sik Kim","orcid":null,"position":3,"is_corresponding":false},{"id":477948,"name":"Olivia N. Hitchcock","orcid":null,"position":4,"is_corresponding":false},{"id":370537,"name":"Zoë A. MacDowell Kaswan","orcid":null,"position":5,"is_corresponding":false},{"id":380889,"name":"Yang In Kim","orcid":"0000-0003-3420-7870","position":6,"is_corresponding":false},{"id":477949,"name":"Gene D. Block","orcid":null,"position":7,"is_corresponding":false},{"id":476737,"name":"Cristina A. Ghiani","orcid":"0000-0002-9867-6185","position":8,"is_corresponding":false},{"id":476738,"name":"Dawn H. Loh","orcid":"0000-0001-7876-5757","position":9,"is_corresponding":false},{"id":380887,"name":"Christopher S. Colwell","orcid":"0000-0002-1059-184X","position":10,"is_corresponding":false},{"id":476734,"name":"Huei‐Bin Wang","orcid":"0000-0002-7141-0950","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32889171","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}