{"doi":"10.1016/j.nbd.2015.11.008","title":"Pathogenesis of severe ataxia and tremor without the typical signs of neurodegeneration","abstract":null,"journal":"Neurobiology of Disease","year":2016,"id":663739,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":330713,"name":"Marife Arancillo","orcid":"0000-0003-0367-6180","position":1,"is_corresponding":false},{"id":1732998,"name":"Annesha King","orcid":null,"position":2,"is_corresponding":false},{"id":271029,"name":"Tao Lin","orcid":"0000-0002-6441-067X","position":3,"is_corresponding":false},{"id":911525,"name":"Lauren N. 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To understand the origins of diseases that do not have an obvious neuropathology, we tested how loss of CAR8, a regulator of IP3R1-mediated Ca(2+)-signaling, influences cerebellar circuit formation and neural function as movement deteriorates. We found that faulty molecular patterning, which shapes functional circuits called zones, leads to alterations in cerebellar wiring and Purkinje cell activity, but not to degeneration. Rescuing Purkinje cell function improved movement and reducing their Ca(2+) influx eliminated ectopic zones. Our findings in Car8(wdl) mutant mice unveil a pathophysiological mechanism that may operate broadly to impact motor and non-motor conditions that do not involve degeneration.","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26586559","pmcid":"PMC4778569","openalex_id":"https://openalex.org/W2179205971","authors":[],"funders":[{"funder_name":"BCM IDDRC","grant_id":"U54HD083092","title":null},{"funder_name":"NINDS","grant_id":"NS089664","title":null},{"funder_name":"F31","grant_id":"NS092264","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS089664","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R25 GM069234","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"F31 NS092264","title":null},{"funder_name":"Bachmann-Strauss Dystonia and Parkinson Foundation Inc.","grant_id":"","title":null},{"funder_name":"National Ataxia Foundation (NAF)","grant_id":"","title":null}],"total_grants":8,"fwci":1.4182,"citation_percentile":0.7890023,"influential_citations":0,"citation_trend":[{"year":2017,"count":6},{"year":2018,"count":5},{"year":2019,"count":8},{"year":2020,"count":9},{"year":2021,"count":9},{"year":2022,"count":4},{"year":2023,"count":8},{"year":2024,"count":3},{"year":2025,"count":7},{"year":2026,"count":1}],"oa_status":"green","license":"cc-by-sa","oa_locations":[{"url":"https://doaj.org/article/ee219fb97b04470aa634cb20167f1c9f","host_type":"repository"},{"url":"https://doaj.org/article/ee219fb97b04470aa634cb20167f1c9f","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0969996115300875?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0969996115300875?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.nbd.2015.11.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26586559","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4778569","host_type":"repository"}],"fields_of_study":["Genetic Neurodegenerative Diseases","Neuroscience and Neuropharmacology Research","Neurological disorders and treatments","Animals","Ataxia","Biomarkers, Tumor","Cerebellum","Chlorzoxazone","Learning","Mice","Mice, Inbred C57BL","Motor Activity","Nerve Tissue Proteins","Neural Pathways","Purkinje Cells","Spinal Cord","Tremor","Tyrosine 3-Monooxygenase","Carbonic Anhydrases"],"mesh_terms":["Animals","Ataxia","Carbonic Anhydrases","Cerebellum","Chlorzoxazone","Learning","Mice, Inbred C57BL","Motor Activity","Nerve Tissue Proteins","Neural Pathways","Purkinje Cells","Spinal Cord","Tremor","Biomarkers, Tumor","Tyrosine 3-Monooxygenase","Mice"],"keywords":["Neurodegeneration","Neuroscience","Ataxia","Neuropathology","Purkinje cell","Cerebellum","Degeneration (medical)","Biology","Medicine","Pathology","Disease","Behavior","Tremor","In Vivo Electrophysiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T23:18:19.563160Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}