{"doi":"10.1016/j.nbas.2022.100044","title":"Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey","abstract":"With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene into rhesus oocytes, followed by in vitro fertilization and embryo transfer. The APP-transgene included the AD-associated Swedish K670N/M671L and Indiana V717F mutations (APPSWE/IND) regulated by the human polyubiquitin-C promoter. Overexpression of APP was confirmed in lymphocytes and brain tissue. Upon sacrifice at 10 years of age, one of the monkeys had developed Aβ plaques and cerebral Aβ-amyloid angiopathy in the occipital, parietal, and caudal temporal neocortices. The induction of Aβ deposition more than a decade prior to its usual emergence in the rhesus monkey supports the feasibility of creating a transgenic nonhuman primate model for mechanistic analyses and preclinical testing of treatments for Alzheimer's disease and cerebrovascular amyloidosis.","journal":"Aging Brain","year":2022,"id":281517,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9398,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":727462,"name":"In Ki Cho","orcid":"0000-0001-8583-9128","position":1,"is_corresponding":false},{"id":366094,"name":"Chunxia Li","orcid":"0000-0001-8102-137X","position":2,"is_corresponding":false},{"id":956725,"name":"Xiaodong Zhang","orcid":"0000-0001-8633-5992","position":3,"is_corresponding":false},{"id":367769,"name":"Sudeep Patel","orcid":null,"position":4,"is_corresponding":false},{"id":957205,"name":"Rebecca Rusnak","orcid":null,"position":5,"is_corresponding":false},{"id":301366,"name":"Jessica Raper","orcid":"0000-0002-0964-9944","position":6,"is_corresponding":false},{"id":344607,"name":"Jocelyne Bachevalier","orcid":"0000-0002-7117-0643","position":7,"is_corresponding":false},{"id":472919,"name":"Sean P. Moran","orcid":"0000-0001-7672-242X","position":8,"is_corresponding":false},{"id":957206,"name":"Tim Chi","orcid":null,"position":9,"is_corresponding":false},{"id":957207,"name":"Katherine H. Cannon","orcid":null,"position":10,"is_corresponding":false},{"id":957208,"name":"Carissa Emerson Hunter","orcid":null,"position":11,"is_corresponding":false},{"id":911273,"name":"Ryan C. Martin","orcid":"0000-0001-6613-7497","position":12,"is_corresponding":false},{"id":289795,"name":"Hailian Xiao","orcid":"0000-0002-3796-4693","position":13,"is_corresponding":false},{"id":956726,"name":"Shang‐Hsun Yang","orcid":"0000-0002-1601-3653","position":14,"is_corresponding":false},{"id":205024,"name":"Sanjeev Gumber","orcid":"0000-0001-9048-2717","position":15,"is_corresponding":false},{"id":280274,"name":"James G. Herndon","orcid":null,"position":16,"is_corresponding":false},{"id":370673,"name":"Rebecca F. Rosen","orcid":"0000-0002-0680-6246","position":17,"is_corresponding":false},{"id":108302,"name":"William T. Hu","orcid":"0000-0003-4862-6777","position":18,"is_corresponding":false},{"id":107095,"name":"James J. Lah","orcid":"0000-0002-8810-620X","position":19,"is_corresponding":false},{"id":68010,"name":"Allan I. Levey","orcid":"0000-0002-3153-502X","position":20,"is_corresponding":false},{"id":266440,"name":"Yoland Smith","orcid":"0000-0002-8700-878X","position":21,"is_corresponding":false},{"id":292691,"name":"Lary C. Walker","orcid":"0000-0001-9166-3261","position":22,"is_corresponding":false},{"id":371728,"name":"Anthony W.S. Chan","orcid":"0000-0002-4388-2280","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T00:29:11.698554Z","pmid":"36589695","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}