{"doi":"10.1016/j.mvr.2019.103973","title":"Up-regulation of brain cytokines and metalloproteinases 1 and 2 contributes to neurological deficit and brain damage in transient ischemic stroke","abstract":null,"journal":"Microvascular Research","year":2020,"id":651865,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1278002,"name":"Eliana Cristina de Brito Toscano","orcid":"0000-0002-8756-0689","position":1,"is_corresponding":false},{"id":1269514,"name":"Fabrício Marcus Silva Oliveira","orcid":"0000-0001-9963-1758","position":2,"is_corresponding":false},{"id":1256397,"name":"Bárbara Andrade de Carvalho","orcid":"0000-0003-3870-3687","position":3,"is_corresponding":false},{"id":1700251,"name":"Marcelo Vidigal Caliari","orcid":null,"position":4,"is_corresponding":false},{"id":3176,"name":"Antônio Lúcio Teixeira","orcid":"0000-0002-9621-5422","position":5,"is_corresponding":false},{"id":887003,"name":"Aline Silva de Miranda","orcid":"0000-0003-2811-7924","position":6,"is_corresponding":false},{"id":436078,"name":"Milene Alvarenga Rachid","orcid":"0000-0002-3142-6552","position":7,"is_corresponding":false},{"id":1700248,"name":"Edna Constanza Gómez Victoria","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Up-regulation of brain cytokines and metalloproteinases 1 and 2 contributes to neurological deficit and brain damage in transient ischemic stroke","abstract":"Ischemic stroke represents a major cause of adult death and severe neurological disability worldwide. Reperfusion following brain ischemia produces an inflammatory cascade that increases brain damage. In this context, matrix metalloproteinases (MMPs) play an important role as pro-inflammatory mediators. The MMP 2 up-regulation seems to promote matrix degradation, blood-brain barrier (BBB) disruption and facilitates the influx of peripheral inflammatory cells to the brain after stroke. However, there are not studies about MMP-1 in this condition. The aim of this study is to evaluate the association of brain damage, inflammatory response and the immunostaining profile of matrix metalloproteinases 1 and 2 after transient global cerebral ischemia. Mice were submitted to bilateral common carotid arterial occlusion (BCCAo) during 25 min. After three days of reperfusion, the neurological deficit score was evaluated and the animals were euthanized. Brain samples were collected in order to analyze the histopathological damage, MMPs 1 and 2 immunostaining and cytokines and chemokines levels. Ischemic group showed neurological deficits associated with brain lesions, characterized by necrotic core and penumbra zone three days after reperfusion. Higher brain immunostaining of MMP-1 and MMP-2 was observed in BCCAo samples than in sham samples. Ischemic group also exhibited increased brain levels of the cytokines tumoral necrosis factor (TNF) and interleukin 1β (IL-1β), chemokine (C-X-C motif) ligand 1 (CXCL1), and chemokine (C-C motif) ligand 5 (CCL5) in comparison to sham group. Our results suggest that the MMP-1 and MMP-2 raise, associated with the up-regulation of inflammatory mediators, contributes to brain damage and neurological deficits after global brain ischemia followed by three days of reperfusion in mice.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31891716","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","grant_id":"449963/2014-4","title":null},{"funder_name":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais","grant_id":"APQ-02437-14","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0026286219302559?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0026286219302559?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Animals","Brain","Chemokine CCL5","Chemokine CXCL1","Cytokines","Disease Models, Animal","Interleukin-1beta","Ischemic Attack, Transient","Male","Matrix Metalloproteinase 13","Matrix Metalloproteinase 2","Mice, Inbred C57BL","Necrosis","Signal Transduction","Tumor Necrosis Factor-alpha","Up-Regulation"],"mesh_terms":["Brain","Animals","Mice, Inbred C57BL","Ischemic Attack, Transient","Disease Models, Animal","Necrosis","Tumor Necrosis Factor-alpha","Cytokines","Signal Transduction","Up-Regulation","Male","Matrix Metalloproteinase 2","Matrix Metalloproteinase 13","Interleukin-1beta","Chemokine CCL5","Chemokine CXCL1"],"keywords":["Reperfusion","Brain ischemia","Inflammation","Metalloproteinases 1 And 2"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T11:04:38.257677Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}