{"doi":"10.1016/j.mvr.2009.10.001","title":"Implanted microvessels progress through distinct neovascularization phenotypes","abstract":null,"journal":"Microvascular Research","year":2010,"id":657106,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1715270,"name":"Kevin A. Greer","orcid":null,"position":1,"is_corresponding":false},{"id":1715272,"name":"Chad M. Stiening","orcid":null,"position":2,"is_corresponding":false},{"id":1715273,"name":"Helen Y.S. Chen","orcid":null,"position":3,"is_corresponding":false},{"id":1715274,"name":"Kameha R. Kidd","orcid":null,"position":4,"is_corresponding":false},{"id":1715275,"name":"Mark A. Schwartz","orcid":null,"position":5,"is_corresponding":false},{"id":1715276,"name":"Chris J. Sullivan","orcid":null,"position":6,"is_corresponding":false},{"id":1182136,"name":"Harish Rekapally","orcid":null,"position":7,"is_corresponding":false},{"id":390015,"name":"James B. Hoying","orcid":"0000-0001-7959-227X","position":8,"is_corresponding":false},{"id":1443860,"name":"Sara S. 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This was followed by a neovascular remodeling phenotype characterized by a perfused, poorly organized neovascular network, reduced proliferation, and re-associated mural cells. The last phenotype included a vascular network organized into a stereotypical tree structure containing vessels with normal perivascular cell associations. In addition, proliferation was low and was restricted to the walls of larger microvessels. The transition from angiogenesis to neovascular remodeling coincided with the appearance of blood flow in the implant neovasculature. Analysis of vascular-specific and global gene expression indicates that the intermediate, neovascular remodeling phenotype is transcriptionally distinct from the other two phenotypes. Therefore, this vascular phenotype likely is not simply a transitional phenotype but a distinct vascular phenotype involving unique cellular and vascular processes. Furthermore, this neovascular remodeling phase may be a normal aspect of the general neovascularization process. Given that this phenotype is arguably dysfunctional, many of the microvasculatures present within compromised or diseased tissues may not represent a failure to progress appropriately through a normally occurring neovascularization phenotype.","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19833141","pmcid":"PMC2813398","openalex_id":"https://openalex.org/W1992287666","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"K02 HL067067","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"P30 GM103507","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL077683","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"R01 EB007556","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL67067","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK078175","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL077683","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"EB007556","title":null}],"total_grants":8,"fwci":1.8897,"citation_percentile":0.84791488,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":7},{"year":2014,"count":6},{"year":2015,"count":10},{"year":2016,"count":2},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2019,"count":7},{"year":2020,"count":3},{"year":2021,"count":9},{"year":2022,"count":9},{"year":2023,"count":7},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0026286209002398?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0026286209002398?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mvr.2009.10.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19833141","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2813398","host_type":"repository"}],"fields_of_study":["Angiogenesis and VEGF in Cancer","Axon Guidance and Neuronal Signaling","Hippo pathway signaling and YAP/TAZ","Adipose Tissue","Animals","Apoptosis","Cell Movement","Cell Proliferation","Female","Gene Expression Regulation","Green Fluorescent Proteins","Male","Mice","Mice, SCID","Mice, Transgenic","Microcirculation","Microvessels","Neovascularization, Physiologic","Phenotype","Principal Component Analysis","Time Factors","Transcription, Genetic"],"mesh_terms":["Adipose Tissue","Animals","Cell Movement","Female","Gene Expression Regulation","Male","Mice, Transgenic","Microcirculation","Phenotype","Time Factors","Transcription, Genetic","Mice, SCID","Apoptosis","Neovascularization, Physiologic","Principal Component Analysis","Cell Proliferation","Green Fluorescent Proteins","Mice","Microvessels"],"keywords":["Phenotype","Angiogenesis","Neovascularization","Sprouting angiogenesis","Mural cell","Biology","Pathology","Cell biology","Cancer research","Endothelial stem cell","Medicine","Gene","Genetics","In vitro"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T23:43:18.008955Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}