{"doi":"10.1016/j.mucimm.2024.10.004","title":"TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways","abstract":"T cells in small intestines from TRIM29-deficient mice. Mechanistically, TRIM29 promoted K48-linked ubiquitination, leading to the degradation of NLRP6 and NLRP9b, resulting in decreased IFN-λ and IL-18 secretion by IECs. Our findings reveal that enteric viruses utilize TRIM29 to inhibit IFN-λ and inflammasome activation in IECs, thereby facilitating viral-induced intestinal inflammation. This indicates that targeting TRIM29 could offer a promising therapeutic strategy for alleviating gut diseases.","journal":"Mucosal Immunology","year":2024,"id":421196,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336313,"name":"Ling Wang","orcid":"0000-0001-7861-2769","position":1,"is_corresponding":false},{"id":16323,"name":"Wenting Lu","orcid":null,"position":2,"is_corresponding":false},{"id":1213294,"name":"Naser Farhataziz","orcid":"0009-0007-1048-8627","position":3,"is_corresponding":false},{"id":1214017,"name":"Anastasia Gonzalez","orcid":null,"position":4,"is_corresponding":false},{"id":469642,"name":"Junji Xing","orcid":"0000-0002-3392-5427","position":5,"is_corresponding":false},{"id":469648,"name":"Zhiqiang Zhang","orcid":"0000-0003-1796-081X","position":6,"is_corresponding":false},{"id":1213293,"name":"Junying Wang","orcid":"0009-0008-2767-4407","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T01:57:36.298171Z","pmid":"39396665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}