{"doi":"10.1016/j.mtbio.2025.102409","title":"Biomimetic nanovesicle vaccines derived from dendritic cells sensitized with whole tumor antigens for melanoma immunotherapy","abstract":null,"journal":"Materials Today Bio","year":2025,"id":645528,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1680930,"name":"Fengze Miao","orcid":null,"position":1,"is_corresponding":false},{"id":1127326,"name":"Yingchao Zhao","orcid":"0000-0001-8362-6735","position":2,"is_corresponding":false},{"id":783560,"name":"Jun Liu","orcid":"0000-0002-8175-6293","position":3,"is_corresponding":false},{"id":1350418,"name":"Yu Meng","orcid":"0000-0003-0013-2102","position":4,"is_corresponding":false},{"id":590509,"name":"Han Yan","orcid":"0000-0003-2789-0798","position":5,"is_corresponding":false},{"id":687801,"name":"Ruyi Wang","orcid":"0000-0001-5832-5391","position":6,"is_corresponding":false},{"id":1680931,"name":"Quangang Zhu","orcid":null,"position":7,"is_corresponding":false},{"id":1680932,"name":"Zongguang Tai","orcid":"0000-0001-5603-745X","position":8,"is_corresponding":false},{"id":308680,"name":"Zhongjian Chen","orcid":"0000-0003-3789-7096","position":9,"is_corresponding":false},{"id":1680928,"name":"Jiaye Lu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biomimetic nanovesicle vaccines derived from dendritic cells sensitized with whole tumor antigens for melanoma immunotherapy","abstract":"Background: Cancer vaccine research has made significant progress in antigen discovery, delivery systems, and combination therapies. However, optimizing antigen selection and delivery remains a current challenge. To address this, we utilized oxidatively treated tumor cells as a source of antigens, effectively enhancing their immunogenicity. Inspired by the antigen delivery capabilities of dendritic cells (DCs) via extracellular vesicles, we developed a novel biomimetic nanovesicle vaccine, diA-MADCVac. This vaccine inherits the targeting ability of DCs, enabling precise antigen delivery to lymph nodes. Moreover, as a carrier, it efficiently delivers both adjuvants and intact tumor antigens, thereby playing a synergistic role in activating the immune system. Result: By targeting lymph nodes, diA-MADCVac effectively induces DCs maturation, activating tumor-specific T cell responses and generating trained immune memory. Furthermore, in a melanoma mouse model, diA-MADCVac significantly altered the tumor microenvironment, triggering a strong anti-tumor immune response and inhibiting tumor growth. This effect was characterized by increased secretion of cytokines such as IFN-γ and TNF-α in the tumor, along with a higher number of infiltrating T cells, which enhanced the immune system's tumor-killing capacity. Conclusion: use. This nanovesicle serves as an effective carrier, efficiently delivering both adjuvants and antigens to lymph nodes, thereby enhancing DC-mediated anti-tumor immune responses. Additionally, diA-MADCVac promotes trained immunity and enhances the tumor-killing capacity of immune cells. With its unique advantages, diA-MADCVac offers an efficient, safe, and promising new approach for tumor treatment, providing renewed hope for cancer patients.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41146660","pmcid":"PMC12554210","openalex_id":"https://openalex.org/W4415091795","authors":[],"funders":[{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"22120240325","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82172706","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82373274","title":null}],"total_grants":3,"fwci":0.8041,"citation_percentile":0.73770019,"influential_citations":0,"citation_trend":[{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.mtbio.2025.102409","host_type":"journal"},{"url":"https://doi.org/10.1016/j.mtbio.2025.102409","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2590006425009809?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2590006425009809?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41146660","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12554210","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12554210","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12554210?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Immunotherapy and Immune Responses","Immune responses and vaccinations","Extracellular vesicles in disease"],"mesh_terms":[],"keywords":["Immune system","Melanoma","Antigen","Immunotherapy","Cancer immunotherapy","Vaccination","Adjuvant","Immunity","Cancer vaccine","Melanoma Immunotherapy","Sting Signaling Pathway","Dendritic Cell Nanovesicle","Whole Tumor Antigens"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T06:30:51.471956Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}