{"doi":"10.1016/j.msard.2023.105408","title":"Clinical and radiological characteristics and outcomes of patients with recurrent or relapsing tumefactive demyelination","abstract":null,"journal":"Multiple Sclerosis and Related Disorders","year":2024,"id":675199,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236498,"name":"Sudarshini Ramanathan","orcid":"0000-0002-0294-9768","position":1,"is_corresponding":false},{"id":1564504,"name":"Cecilia Cappelen-Smith","orcid":null,"position":2,"is_corresponding":false},{"id":1468714,"name":"Steve Vucic","orcid":"0000-0002-0956-4633","position":3,"is_corresponding":false},{"id":1764176,"name":"Stephen W. Reddel","orcid":null,"position":4,"is_corresponding":false},{"id":1298989,"name":"Todd A. Hardy","orcid":"0000-0003-4145-3172","position":5,"is_corresponding":false},{"id":1764175,"name":"Irin Pervin","orcid":"0009-0005-7275-6311","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical and radiological characteristics and outcomes of patients with recurrent or relapsing tumefactive demyelination","abstract":"<h4>Background</h4>Relapsing or recurrent tumefactive demyelination is rare and has not been studied beyond individual case reports.<h4>Objective</h4>We examined the clinical course, neuroimaging, cerebrospinal fluid (CSF), treatment and outcomes of patients with recurrent tumefactive demyelinating lesions (TDLs).<h4>Methods</h4>We used PubMed to identify reports of recurrent TDLs and included the details of an additional, unpublished patient.<h4>Results</h4>We identified 18 cases (11F, 7 M). The median age at onset of the index TDL was 37 years (range 12-72) and most were solitary lesions 72 % (13/18). CSF-restricted oligoclonal bands (OCBs) were detected in 25 % (4/16). Only one of those tested (n = 13) was positive for AQP4-IgG. A moderate-to-marked treatment response (high dose corticosteroid with or without additional plasmapheresis, IVIg or disease modifying therapies) was evident in 89 % of treated patients. Median EDSS at the median follow-up of 36 months (range 6-144) was 2 (range 1-10). Most remained ambulatory (EDSS < 4 in 13/18), but 1 patient died.<h4>Conclusion</h4>The median age of patients with relapsing TDLs is similar to that of typical MS, but differences include a lower female:male sex ratio, larger lesions, and a comparative lack of CSF-restricted OCBs. Outcomes vary among this group of patients ranging from minimal disability through to death.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38219394","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.msard-journal.com/article/S2211034823009070/pdf","host_type":"HYBRID"},{"url":"http://www.msard-journal.com/article/S2211034823009070/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211034823009070?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211034823009070?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.msard.2023.105408","host_type":"Unpaywall"}],"fields_of_study":["Medicine"],"mesh_terms":["Humans","Multiple Sclerosis","Demyelinating Diseases","Recurrence","Adrenal Cortex Hormones","Magnetic Resonance Imaging","Radiography","Retrospective Studies","Adolescent","Adult","Aged","Middle Aged","Child","Female","Male","Young Adult","Neuroimaging"],"keywords":["Therapy","MRI","Prognosis","Multiple sclerosis","Adem","Pseudotumoral","Pseudotumour","Balo Concentric Sclerosis","Nmosd","Demyelinating","Mogad"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T20:14:46.018214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}