{"doi":"10.1016/j.mri.2021.11.008","title":"Magnetic resonance molecular imaging of extradomain B fibronectin enables detection of pancreatic ductal adenocarcinoma metastasis","abstract":"Extradomain-B Fibronectin (EDB-FN) is an oncomarker that can be visualized with magnetic resonance molecular imaging (MRMI) to detect pancreatic ductal adenocarcinoma (PDAC) metastasis. In this study, we sought to assess the expression of EDB-FN in clinical samples of PDAC and to evaluate MRMI of PDAC metastasis with an EDB-FN-specific gadolinium-based contrast agent (MT218) in an orthotopic KPC-GFP-Luc mouse model. EDB-FN expression was evaluated in PDAC tissue samples through immunohistochemistry. RNA-Seq data obtained from the GEPIA2 project was evaluated to demonstrate EDB-FN expression in large patient cohorts. FLASH-3D MRI at 3 T of the KPC-GFP-Luc metastasis model was performed following injection of MT218. Tumor enhancement in MR images was correlated to postmortem distribution of KPC-GFP-Luc tumors using fluorescent and bright-field cryo-imaging and anatomical landmarks. EDB-FN immunohistochemical staining scores of human metastatic tumor stroma, (2.17 ± 0.271), metastatic tumor parenchyma (2.08 ± 0.229), primary tumor stroma (1.61 ± 0.26), and primary tumor parenchyma (1.61 ± 0.12) were significantly (p < 0.0001) higher than normal pancreas stroma (0.14 ± 0.10) and normal pancreas parenchyma (0.14 ± 0.14). EDB-FN mRNA expression in tumors is 4.98 log2(TPM + 1) and 0.18 log2(TPM + 1) in normal tissue (p < 0.01). A mouse model of EDB-FN rich PDAC metastasis exhibited T1-weighted contrast to noise (CNR) changes of 21.80 ± 4.34 in perimetastatic regions and 8.38 ± 0.79 in metastatic regions identified through cryo-imaging, significantly higher (p < 0.05) than CNR changes found in normal liver (−6.43 ± 0.92), mesentery (2.24 ± 0.92), spleen (−3.06 ± 2.38) and intestine (1.08 ± 2.15). We conclude that EDB-FN is overexpressed in metastatic and primary PDAC tumors and MRMI with MT218 enables the detection of metastatic and perimetastatic tissues.","journal":"Magnetic Resonance Imaging","year":2021,"id":177952,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":723708,"name":"Mahdusudhana Gargesha","orcid":null,"position":1,"is_corresponding":false},{"id":722990,"name":"Yiqiao Liu","orcid":"0000-0003-1071-5475","position":2,"is_corresponding":false},{"id":655074,"name":"Victoria Laney","orcid":"0000-0003-1188-6591","position":3,"is_corresponding":false},{"id":702372,"name":"Ryan Hall","orcid":"0000-0003-2674-7834","position":4,"is_corresponding":false},{"id":365445,"name":"Amita Vaidya","orcid":null,"position":5,"is_corresponding":false},{"id":365448,"name":"Hannah Gilmore","orcid":null,"position":6,"is_corresponding":false},{"id":722991,"name":"Kara L. Gawelek","orcid":"0000-0002-5220-5513","position":7,"is_corresponding":false},{"id":446183,"name":"Bryan Scott","orcid":null,"position":8,"is_corresponding":false},{"id":374175,"name":"Debashish Roy","orcid":"0009-0009-9940-1907","position":9,"is_corresponding":false},{"id":311212,"name":"David L. Wilson","orcid":"0000-0001-9763-1463","position":10,"is_corresponding":false},{"id":364020,"name":"Zheng‐Rong Lu","orcid":"0000-0001-8185-9519","position":11,"is_corresponding":false},{"id":364017,"name":"Peter Qiao","orcid":"0000-0001-7495-354X","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:47:36.112170Z","pmid":"34801672","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}