{"doi":"10.1016/j.mrgentox.2017.06.007","title":"DNA damage and the bystander response in tumor and normal cells exposed to X-rays","abstract":null,"journal":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","year":2017,"id":642801,"datarank":0.6619194757859754,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.2660608763436866,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.2660608763436866,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":10,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1672170,"name":"R. Venkateswarlu","orcid":null,"position":1,"is_corresponding":false},{"id":1672171,"name":"K. Karthik","orcid":null,"position":2,"is_corresponding":false},{"id":1672172,"name":"V. Shangamithra","orcid":null,"position":3,"is_corresponding":false},{"id":1672173,"name":"P. Venkatachalam","orcid":null,"position":4,"is_corresponding":false},{"id":1672169,"name":"M. Subhashree","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DNA damage and the bystander response in tumor and normal cells exposed to X-rays","abstract":"Monolayer and suspension cultures of tumor (BMG-1, CCRF-CEM), normal (AG1522, HADF, lymphocytes) and ATM-mutant (GM4405) human cells were exposed to X-rays at doses used in radiotherapy (high dose and high dose-rate) or radiological imaging (low dose and low dose-rate). Radiation-induced DNA damage, its persistence, and possible bystander effects were evaluated, based on DNA damage markers (γ-H2AX, p53<sup>ser15</sup>) and cell-cycle-specific cyclins (cyclin B1 and cyclin D1). Dose-dependent DNA damage and a dose-independent bystander response were seen after exposure to high dose and high dose-rate radiation. The level of induced damage (expression of p53<sup>ser15</sup>, γ-H2AX) depended on ATM status. However, low dose and dose-rate exposures neither increased expression of marker proteins nor induced a bystander response, except in the CCRF-CEM cells. Bystander effects after high-dose irradiation may contribute to stochastic and deterministic effects. Precautions to protect unexposed regions or to inhibit transmission of DNA damage signaling might reduce radiation risks.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28735740","pmcid":null,"openalex_id":"https://openalex.org/W2728865991","authors":[],"funders":[{"funder_name":"Department of Science and Technology","grant_id":"SR-SO/HS-127/2012","title":null},{"funder_name":"Atomic Energy Regulatory Board","grant_id":"58/04/2014","title":null}],"total_grants":2,"fwci":1.3519,"citation_percentile":0.79881126,"influential_citations":0,"citation_trend":[{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1383571817301420?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1383571817301420?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mrgentox.2017.06.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28735740","host_type":"repository"}],"fields_of_study":["Effects of Radiation Exposure","Radiation Therapy and Dosimetry","DNA Repair Mechanisms","Bystander Effect","Cell Culture Techniques","Cell Line, Tumor","Cyclin B1","Cyclin D1","DNA Damage","DNA, Neoplasm","Dose-Response Relationship, Radiation","Fibroblasts","Histones","Humans","Lymphocytes","Mutation","Tumor Suppressor Protein p53","X-Rays"],"mesh_terms":["DNA Damage","DNA, Neoplasm","Dose-Response Relationship, Radiation","Fibroblasts","Histones","Humans","Lymphocytes","Mutation","X-Rays","Tumor Suppressor Protein p53","Cell Culture Techniques","Cyclin D1","Bystander Effect","Cell Line, Tumor","Cyclin B1"],"keywords":["Bystander effect","DNA damage","Cancer research","DNA repair","Cell cycle","Dose–response relationship","Molecular biology","Apoptosis","Biology","Chemistry","DNA","Immunology","Genetics","Pharmacology","ATM","cyclins","Γ-h2ax","P(53)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T03:54:39.241424Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}