{"doi":"10.1016/j.mrfmmm.2004.05.025","title":"Clinicopathologic features in colorectal cancer patients with microsatellite instability","abstract":null,"journal":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","year":2004,"id":614073,"datarank":0.6394019815561974,"base_score":4.2626798770413155,"endowment":4.2626798770413155,"self_citation_contribution":0.6394019815561974,"citation_network_contribution":0.0,"self_endowment_contribution":0.6394019815561974,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334151,"name":"Timothy M. Pawlik","orcid":"0000-0002-4828-8096","position":1,"is_corresponding":false},{"id":1582289,"name":"Miguel A. Rodriguez-Bigas","orcid":null,"position":2,"is_corresponding":false},{"id":69792,"name":"Chandrajit P. Raut","orcid":"0000-0001-7297-3221","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinicopathologic features in colorectal cancer patients with microsatellite instability","abstract":"The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a small but significant proportion of colorectal cancers. While MSI is identified in most cancers in individuals with hereditary non-polyposis colorectal cancer, the majority of MSI tumors are found in individuals with sporadic disease. Colorectal cancers arising as a result of MSI have distinct clinicopathologic features distinguishing them from those with microsatellite stability. MSI colorectal cancers affect a larger percentage of women, are usually localized proximal to the splenic flexure, and have a higher incidence of synchronous and metachronous tumors. They are associated with a mucinous histology, tumor-infiltrating lymphocytes, a Crohn's-like inflammatory response, and a higher grade but lower stage. Overall survival is better in individuals with MSI. The benefit of chemotherapy in MSI colorectal cancers, with and without lymph node metastases, remains unclear.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15542114","pmcid":null,"openalex_id":"https://openalex.org/W15542114","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.0,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0027510704003446?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0027510704003446?httpAccept=text/plain","host_type":"publisher"},{"url":"http://ci.nii.ac.jp/ncid/BA90126178","host_type":"ebook platform"}],"fields_of_study":["Genetic factors in colorectal cancer","Colorectal Cancer Treatments and Studies","Colorectal Cancer Screening and Detection","Base Pair Mismatch","Colorectal Neoplasms","DNA Methylation","DNA Repair","Drug Therapy","Genomic Instability","Humans","Microsatellite Repeats","Mutation","Prognosis"],"mesh_terms":["Humans","Colorectal Neoplasms","Genomic Instability","Prognosis","Drug Therapy","DNA Methylation","DNA Repair","Microsatellite Repeats","Mutation","Base Pair Mismatch"],"keywords":["Test of English as a Foreign Language","Test (biology)","Psychology","Mathematics education","Geology","Language assessment"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T10:34:24.828581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}