{"doi":"10.1016/j.molimm.2022.11.009","title":"The second-generation tyrosine kinase inhibitor afatinib inhibits IL-1β secretion via blocking assembly of NLRP3 inflammasome independent of epidermal growth factor receptor signaling in macrophage","abstract":null,"journal":"Molecular Immunology","year":2023,"id":634686,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1646215,"name":"Jiafeng Liang","orcid":null,"position":1,"is_corresponding":false},{"id":346,"name":"Yanyan Zhao","orcid":"0000-0003-4978-1410","position":2,"is_corresponding":false},{"id":490886,"name":"Jingjing Zhang","orcid":"0000-0002-1349-9184","position":3,"is_corresponding":false},{"id":31212,"name":"Xueqin Chen","orcid":"0000-0001-9444-5059","position":4,"is_corresponding":false},{"id":617549,"name":"Hong Jiang","orcid":"0000-0002-0038-8960","position":5,"is_corresponding":false},{"id":567065,"name":"Zhen Zhang","orcid":"0000-0002-1840-3110","position":6,"is_corresponding":false},{"id":150024,"name":"Shenglin Ma","orcid":null,"position":7,"is_corresponding":false},{"id":1646221,"name":"Shirong Zhang","orcid":null,"position":8,"is_corresponding":false},{"id":1646214,"name":"Shujun Xie","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The second-generation tyrosine kinase inhibitor afatinib inhibits IL-1β secretion via blocking assembly of NLRP3 inflammasome independent of epidermal growth factor receptor signaling in macrophage","abstract":"Chronic inflammation might lead to many malignancies, and inadequate resolution could play a crucial role in tumor invasion, progression and metastases. Afatinib is a second-generation tyrosine kinase inhibitor targeting epidermal growth factor receptor in non-small cell lung cancer. Few studies showed the correlation of afatinib and the innate immune system especially macrophage. Our study showed that afatinib could block the activation of NLRP3 inflammasome in a dose-dependent manner in macrophage, and that afatinib could prevent the assembly of NLRP3 inflammasome. Besides, afatinib could inhibit NLRP3 inflammasome activation independent of EGFR signaling. Moreover, afatinib was able to alleviate the LPS-induced sepsis in vivo. These investigations provide significant experimental evidence in afatinib as therapeutic drug for non-small cell lung cancer or other tumors and NLRP3-related diseases, and explore new target for afatinib in macrophage.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36495818","pmcid":null,"openalex_id":"https://openalex.org/W4311284234","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82003017","title":null},{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LQ20H310004","title":null},{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LY21H160018","title":null}],"total_grants":3,"fwci":0.3921,"citation_percentile":0.55487641,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0161589022004709/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0161589022004709/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0161589022004709?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0161589022004709?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.molimm.2022.11.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36495818","host_type":"repository"}],"fields_of_study":["Inflammasome and immune disorders","Cancer Immunotherapy and Biomarkers","Fibroblast Growth Factor Research","Humans","Afatinib","Carcinoma, Non-Small-Cell Lung","ErbB Receptors","Inflammasomes","Lung Neoplasms","Macrophages","NLR Family, Pyrin Domain-Containing 3 Protein","Tyrosine Kinase Inhibitors"],"mesh_terms":["NLR Family, Pyrin Domain-Containing 3 Protein","Afatinib","Tyrosine Kinase Inhibitors","Carcinoma, Non-Small-Cell Lung","Humans","Lung Neoplasms","Macrophages","Inflammasomes","ErbB Receptors"],"keywords":["Afatinib","Inflammasome","Cancer research","Tyrosine kinase","Epidermal growth factor receptor","Macrophage","Inflammation","Signal transduction","Immunology","Biology","Medicine","Cancer","Cell biology","Erlotinib","Internal medicine","Biochemistry","EGFR","Nlrp3","Tki"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:01:34.441657Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}