{"doi":"10.1016/j.molcel.2024.08.010","title":"Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation","abstract":"RNA interactome studies have revealed that hundreds of zinc-finger proteins (ZFPs) are candidate RNA-binding proteins (RBPs), yet their RNA substrates and functional significance remain largely uncharacterized. Here, we present a systematic multi-omics analysis of the DNA- and RNA-binding targets and regulatory roles of more than 100 ZFPs representing 37 zinc-finger families. We show that multiple ZFPs are previously unknown regulators of RNA splicing, alternative polyadenylation, stability, or translation. The examined ZFPs show widespread sequence-specific RNA binding and preferentially bind proximal to transcription start sites. Additionally, several ZFPs associate with their targets at both the DNA and RNA levels. We highlight ZNF277, a C2H2 ZFP that binds thousands of RNA targets and acts as a multi-functional RBP. We also show that ZNF473 is a DNA/RNA-associated protein that regulates the expression and splicing of cell cycle genes. Our results reveal diverse roles for ZFPs in transcriptional and post-transcriptional gene regulation.","journal":"Molecular Cell","year":2024,"id":419160,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9384,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":43225,"name":"Lijun Zhan","orcid":"0000-0003-3982-7884","position":1,"is_corresponding":false},{"id":43109,"name":"Sara Olson","orcid":"0009-0009-1064-9974","position":2,"is_corresponding":false},{"id":43198,"name":"Xintao Wei","orcid":null,"position":3,"is_corresponding":false},{"id":1034379,"name":"Jack T. Naritomi","orcid":"0000-0001-7746-7467","position":4,"is_corresponding":false},{"id":991010,"name":"Grady G. Nguyen","orcid":"0009-0005-0512-3522","position":5,"is_corresponding":false},{"id":750128,"name":"Lena Annika Street","orcid":"0000-0002-5473-6713","position":6,"is_corresponding":false},{"id":254941,"name":"Grant A. Goda","orcid":"0000-0002-7325-2490","position":7,"is_corresponding":false},{"id":1208463,"name":"Francisco F. Cavazos","orcid":"0009-0000-1804-9601","position":8,"is_corresponding":false},{"id":264300,"name":"Jonathan C. Schmok","orcid":"0000-0002-5173-902X","position":9,"is_corresponding":false},{"id":1209130,"name":"Manya Jain","orcid":null,"position":10,"is_corresponding":false},{"id":1208464,"name":"Easin Uddin Syed","orcid":"0000-0002-2225-3231","position":11,"is_corresponding":false},{"id":1208465,"name":"Eun‐Jeong Kwon","orcid":"0000-0003-4225-0270","position":12,"is_corresponding":false},{"id":236070,"name":"Wenhao Jin","orcid":"0000-0002-7885-3527","position":13,"is_corresponding":false},{"id":80490,"name":"Eric Kofman","orcid":"0000-0001-5462-9099","position":14,"is_corresponding":false},{"id":625325,"name":"Alexandra Tankka","orcid":"0000-0003-3337-5725","position":15,"is_corresponding":false},{"id":849581,"name":"Allison Li","orcid":"0000-0001-5617-0568","position":16,"is_corresponding":false},{"id":1209131,"name":"Valerie Gonzalez","orcid":null,"position":17,"is_corresponding":false},{"id":43264,"name":"Éric Lécuyer","orcid":"0000-0002-4383-342X","position":18,"is_corresponding":false},{"id":1208466,"name":"Daniel Dominguez","orcid":"0000-0002-8630-2776","position":19,"is_corresponding":false},{"id":17835,"name":"Marko Jovanovic","orcid":"0000-0001-9707-3377","position":20,"is_corresponding":false},{"id":42997,"name":"Brenton R. Graveley","orcid":"0000-0001-5777-5892","position":21,"is_corresponding":false},{"id":43290,"name":"G Yeo","orcid":null,"position":22,"is_corresponding":false},{"id":418342,"name":"Maya L. Gosztyla","orcid":"0000-0003-4758-4800","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-19T01:57:14.586331Z","pmid":"39303722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}