{"doi":"10.1016/j.molcel.2023.12.024","title":"SATB2 organizes the 3D genome architecture of cognition in cortical neurons","abstract":"The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and accessibility in control versus SATB2-deficient cortical neurons. We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing their expression. It also alters A/B compartments, topologically associating domains, and frequently interacting regions. Genes linked to SATB2-dependent 3D genome changes are implicated in highly specialized neuronal functions and contribute to cognitive ability and risk for neuropsychiatric and neurodevelopmental disorders. Non-coding DNA regions with a SATB2-dependent structure are enriched for common variants associated with educational attainment, intelligence, and schizophrenia. Our data establish SATB2 as a cell-type-specific 3D genome modulator, which operates both independently and in cooperation with CCCTC-binding factor (CTCF) to set up the chromatin landscape of pyramidal neurons for cognitive processes.","journal":"Molecular Cell","year":2024,"id":424464,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348985,"name":"Sergio Espeso‐Gil","orcid":"0000-0001-9145-3870","position":1,"is_corresponding":false},{"id":1221430,"name":"Paola Chietera","orcid":null,"position":2,"is_corresponding":false},{"id":1221431,"name":"Amelie Nagel","orcid":null,"position":3,"is_corresponding":false},{"id":1220925,"name":"Aodán Laighneach","orcid":"0000-0003-4853-8953","position":4,"is_corresponding":false},{"id":28805,"name":"Derek W. Morris","orcid":"0000-0002-3413-570X","position":5,"is_corresponding":false},{"id":460842,"name":"Prashanth Rajarajan","orcid":"0000-0002-1240-6716","position":6,"is_corresponding":false},{"id":21362,"name":"Schahram Akbarian","orcid":"0000-0001-7700-0891","position":7,"is_corresponding":false},{"id":557310,"name":"Georg Dechant","orcid":"0000-0003-2011-9415","position":8,"is_corresponding":false},{"id":557307,"name":"Galina Apostolova","orcid":"0000-0003-2682-4385","position":9,"is_corresponding":false},{"id":1220924,"name":"Nico Wahl","orcid":"0000-0001-6220-7873","position":0,"is_corresponding":true}],"reference_count":132,"raw_metadata":null,"created_at":"2026-07-19T01:58:07.191194Z","pmid":"38244545","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}