{"doi":"10.1016/j.molcel.2023.11.024","title":"Transcriptional reprogramming at the intersection of the heat shock response and proteostasis","abstract":null,"journal":"Molecular Cell","year":2024,"id":598645,"datarank":0.6554171778700533,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"self_citation_contribution":0.6554171778700533,"citation_network_contribution":0.0,"self_endowment_contribution":0.6554171778700533,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1534191,"name":"Jenny Joutsen","orcid":null,"position":1,"is_corresponding":false},{"id":659734,"name":"Lea Sistonen","orcid":"0000-0003-1341-2867","position":2,"is_corresponding":false},{"id":1534190,"name":"Jenny C. Pessa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transcriptional reprogramming at the intersection of the heat shock response and proteostasis","abstract":"Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors. To mitigate the stress-induced damage, cells activate transient survival programs. The heat shock response (HSR) is an evolutionarily well-conserved survival program that is activated in response to proteotoxic stress. The HSR encompasses a dual regulation of transcription, characterized by rapid activation of genes encoding molecular chaperones and concomitant global attenuation of non-chaperone genes. Recent genome-wide approaches have delineated the molecular depth of stress-induced transcriptional reprogramming. The dramatic rewiring of gene and enhancer networks is driven by key transcription factors, including heat shock factors (HSFs), that together with chromatin-modifying enzymes remodel the 3D chromatin architecture, determining the selection of either gene activation or repression. Here, we highlight the current advancements of molecular mechanisms driving transcriptional reprogramming during acute heat stress. We also discuss the emerging implications of HSF-mediated stress signaling in the context of physiological and pathological conditions.","is_dataset_classified":null,"base_score":4.31748811353631,"endowment":4.31748811353631,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38103561","pmcid":null,"openalex_id":"https://openalex.org/W4389795851","authors":[],"funders":[],"total_grants":0,"fwci":6.9085,"citation_percentile":0.98142531,"influential_citations":0,"citation_trend":[{"year":2024,"count":16},{"year":2025,"count":35},{"year":2026,"count":23}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.molcel.2023.11.024","host_type":"journal"},{"url":"https://doi.org/10.1016/j.molcel.2023.11.024","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276523009693?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276523009693?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38103561","host_type":"repository"},{"url":"https://research.abo.fi/en/publications/579908c2-12a3-403c-a491-388e2a4657bb","host_type":"repository"},{"url":"https://www.utupub.fi/handle/10024/189485","host_type":"repository"},{"url":"https://research.abo.fi/ws/files/65594933/PIIS1097276523009693.pdf","host_type":"repository"}],"fields_of_study":["Heat shock proteins research","RNA Research and Splicing","Genomics and Chromatin Dynamics","Proteostasis","Transcription Factors","Heat-Shock Response","Molecular Chaperones","Chromatin","Heat Shock Transcription Factors"],"mesh_terms":["Proteostasis","Heat Shock Transcription Factors","Chromatin","Transcription Factors","Molecular Chaperones","Heat-Shock Response"],"keywords":["Biology","Proteostasis","Reprogramming","Heat shock","Cell biology","Chromatin","Heat shock factor","Cellular stress response","Heat shock protein","Transcription factor","Psychological repression","Gene silencing","HSF1","Enhancer","Regulation of gene expression","Gene","Transcriptome","Genetics","Gene expression","Fight-or-flight response","Hsp70","Transcription","Heat shock response","HSR","RNA polymerase II","Post-translational modification","Pol Ii","Hsf","Ptm"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:04:06.763465Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}