{"doi":"10.1016/j.molcel.2020.10.030","title":"A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits","abstract":"Autophagy eliminates cytoplasmic content selected by autophagy receptors, which link cargo to the membrane-bound autophagosomal ubiquitin-like protein Atg8/LC3. Here, we report a selective autophagy pathway for protein condensates formed by endocytic proteins in yeast. In this pathway, the endocytic protein Ede1 functions as a selective autophagy receptor. Distinct domains within Ede1 bind Atg8 and mediate phase separation into condensates. Both properties are necessary for an Ede1-dependent autophagy pathway for endocytic proteins, which differs from regular endocytosis and does not involve other known selective autophagy receptors but requires the core autophagy machinery. Cryo-electron tomography of Ede1-containing condensates, at the plasma membrane and in autophagic bodies, shows a phase-separated compartment at the beginning and end of the Ede1-mediated selective autophagy route. Our data suggest a model for autophagic degradation of macromolecular protein complexes by the action of intrinsic autophagy receptors.","journal":"Molecular Cell","year":2020,"id":53195,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":121,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9478,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270905,"name":"Chia‐Wei Lee","orcid":"0000-0002-8925-7421","position":1,"is_corresponding":false},{"id":270906,"name":"Philipp S. Erdmann","orcid":"0000-0001-8289-9133","position":2,"is_corresponding":false},{"id":270907,"name":"Yumei Zheng","orcid":"0000-0002-4033-2670","position":3,"is_corresponding":false},{"id":270908,"name":"Dawafuti Sherpa","orcid":"0000-0001-7815-5895","position":4,"is_corresponding":false},{"id":270909,"name":"Stefan Jentsch","orcid":"0000-0003-4033-9714","position":5,"is_corresponding":false},{"id":270910,"name":"Boris Pfander","orcid":"0000-0003-2180-5054","position":6,"is_corresponding":false},{"id":241650,"name":"Brenda A. Schulman","orcid":"0000-0002-3083-1126","position":7,"is_corresponding":false},{"id":270911,"name":"Wolfgang Baumeister","orcid":"0000-0001-8154-8809","position":8,"is_corresponding":false},{"id":270904,"name":"Florian Wilfling","orcid":"0000-0002-6559-7261","position":0,"is_corresponding":true}],"reference_count":118,"raw_metadata":null,"created_at":"2026-07-18T20:44:25.349797Z","pmid":"33207182","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}