{"doi":"10.1016/j.molcel.2020.04.026","title":"Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA","abstract":"Structural maintenance of chromosomes (SMC) complexes are essential for genome organization from bacteria to humans, but their mechanisms of action remain poorly understood. Here, we characterize human SMC complexes condensin I and II and unveil the architecture of the human condensin II complex, revealing two putative DNA-entrapment sites. Using single-molecule imaging, we demonstrate that both condensin I and II exhibit ATP-dependent motor activity and promote extensive and reversible compaction of double-stranded DNA. Nucleosomes are incorporated into DNA loops during compaction without being displaced from the DNA, indicating that condensin complexes can readily act upon nucleosome-bound DNA molecules. These observations shed light on critical processes involved in genome organization in human cells.","journal":"Molecular Cell","year":2020,"id":50370,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":196,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":247318,"name":"Erin Cutts","orcid":"0000-0003-3290-4293","position":1,"is_corresponding":false},{"id":247319,"name":"Dongqing Pan","orcid":"0000-0003-3701-8442","position":2,"is_corresponding":false},{"id":247320,"name":"Fabienne Beuron","orcid":"0000-0003-1513-6181","position":3,"is_corresponding":false},{"id":247321,"name":"Thangavelu Kaliyappan","orcid":"0000-0002-3642-0758","position":4,"is_corresponding":false},{"id":248806,"name":"Chaoyou Xue","orcid":null,"position":5,"is_corresponding":false},{"id":247322,"name":"Edward P. Morris","orcid":"0000-0003-3544-0041","position":6,"is_corresponding":false},{"id":248807,"name":"Andrea Musacchio","orcid":null,"position":7,"is_corresponding":false},{"id":247323,"name":"Alessandro Vannini","orcid":"0000-0001-7212-5425","position":8,"is_corresponding":false},{"id":247324,"name":"Eric C. Greene","orcid":"0000-0002-7387-824X","position":9,"is_corresponding":false},{"id":247317,"name":"Muwen Kong","orcid":"0000-0002-7845-1165","position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":null,"created_at":"2026-07-18T20:38:25.860949Z","pmid":"32445620","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}