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Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28732205","pmcid":null,"openalex_id":"https://openalex.org/W2738093081","authors":[],"funders":[{"funder_name":"Research Grants Council of Hong Kong","grant_id":"GRF16138716","title":null},{"funder_name":"Research Grants Council of Hong Kong","grant_id":"GRF16104115","title":null},{"funder_name":"Research Grants Council of Hong Kong","grant_id":"GRF16143016","title":null},{"funder_name":"Research Grants Council of Hong 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