{"doi":"10.1016/j.molcel.2013.08.039","title":"Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1","abstract":null,"journal":"Molecular Cell","year":2013,"id":634981,"datarank":0.7454719949364003,"base_score":4.969813299576001,"endowment":4.969813299576001,"self_citation_contribution":0.7454719949364003,"citation_network_contribution":0.0,"self_endowment_contribution":0.7454719949364003,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":143,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1647140,"name":"Jutta Moehlenbrink","orcid":null,"position":1,"is_corresponding":false},{"id":943540,"name":"Yi-Chien Lu","orcid":null,"position":2,"is_corresponding":false},{"id":1518933,"name":"Lykourgos-Panagiotis Zalmas","orcid":null,"position":3,"is_corresponding":false},{"id":1647143,"name":"Cari A. Sagum","orcid":null,"position":4,"is_corresponding":false},{"id":1647145,"name":"Simon Carr","orcid":null,"position":5,"is_corresponding":false},{"id":1647147,"name":"Joanna F. McGouran","orcid":null,"position":6,"is_corresponding":false},{"id":1647148,"name":"Leila Alexander","orcid":null,"position":7,"is_corresponding":false},{"id":552157,"name":"Oleg Fedorov","orcid":"0000-0002-8662-7300","position":8,"is_corresponding":false},{"id":1647149,"name":"Shonagh Munro","orcid":null,"position":9,"is_corresponding":false},{"id":1512587,"name":"Benedikt Kessler","orcid":null,"position":10,"is_corresponding":false},{"id":1647150,"name":"Mark T. Bedford","orcid":null,"position":11,"is_corresponding":false},{"id":380353,"name":"Qiang Yu","orcid":"0000-0003-1792-7550","position":12,"is_corresponding":false},{"id":1647151,"name":"Nicholas B. La Thangue","orcid":null,"position":13,"is_corresponding":false},{"id":1647138,"name":"Shunsheng Zheng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1","abstract":"The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. Methylation by PRMT1 hinders methylation by PRMT5, which augments E2F-1-dependent apoptosis, whereas PRMT5-dependent methylation favors proliferation by antagonizing methylation by PRMT1. The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity.","is_dataset_classified":null,"base_score":4.969813299576001,"endowment":4.969813299576001,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24076217","pmcid":null,"openalex_id":"https://openalex.org/W2097511227","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"2R01DK062248-05A2","title":"The Functional Analysis of the Coactivator CARM1"},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK062248","title":null},{"funder_name":"Cancer Research UK","grant_id":"13058","title":null},{"funder_name":"Cancer Research UK","grant_id":"300/A13058","title":null},{"funder_name":"Medical Research Council","grant_id":"G1000807","title":null},{"funder_name":"Wellcome Trust","grant_id":"092809","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK062248","title":null}],"total_grants":7,"fwci":4.8152,"citation_percentile":0.96073454,"influential_citations":0,"citation_trend":[{"year":2014,"count":11},{"year":2015,"count":13},{"year":2016,"count":11},{"year":2017,"count":12},{"year":2018,"count":10},{"year":2019,"count":16},{"year":2020,"count":15},{"year":2021,"count":13},{"year":2022,"count":3},{"year":2023,"count":12},{"year":2024,"count":9},{"year":2025,"count":11},{"year":2026,"count":7}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1097276513006394/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1097276513006394/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276513006394?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276513006394?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.molcel.2013.08.039","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24076217","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129656","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:4802f92a-9254-45f2-bb1b-f4f9a4acc598","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:e951de20-8e7f-4e97-8a1a-2fe47f7b398e","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.molcel.2013.08.039","host_type":""},{"url":"https://dx.doi.org/10.1016/j.molcel.2013.08.039","host_type":""}],"fields_of_study":["Cancer-related gene regulation","Epigenetics and DNA Methylation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Amino Acid Motifs","Apoptosis","Arginine","Cell Line, Tumor","Cell Proliferation","Chromatin Assembly and Disassembly","Cyclin A","DNA Damage","E2F1 Transcription Factor","Gene Expression Regulation","Humans","Methylation","Promoter Regions, Genetic","Protein Binding","Protein Processing, Post-Translational","Protein-Arginine N-Methyltransferases","RNA Interference","Repressor Proteins","Signal Transduction","Transcription, Genetic","Transfection"],"mesh_terms":["Arginine","DNA Damage","Gene Expression Regulation","Humans","Methylation","Promoter Regions, Genetic","Protein-Arginine N-Methyltransferases","Protein Binding","Protein Processing, Post-Translational","Repressor Proteins","Transcription, Genetic","Transfection","Signal Transduction","Apoptosis","Cyclin A","Amino Acid Motifs","RNA Interference","Chromatin Assembly and Disassembly","Cell Line, Tumor","Cell Proliferation","E2F1 Transcription Factor"],"keywords":["Methylation","Protein arginine methyltransferase 5","E2F","Biology","Methyltransferase","DNA methylation","Arginine","Cancer research","Cell biology","Cell cycle","Apoptosis","Genetics","DNA","Gene expression","Gene","Amino acid","Protein-Arginine N-Methyltransferases","Transcription, Genetic","Amino Acid Motifs","Cyclin A","Chromatin Assembly and Disassembly","Repressor Proteins","Gene Expression Regulation","Cell Line, Tumor","Humans","RNA Interference","Promoter Regions, Genetic","Molecular Biology","Protein Processing, Post-Translational","E2F1 Transcription Factor","Cell Proliferation","DNA Damage","Protein Binding","Signal Transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:28:57.784867Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}