{"doi":"10.1016/j.molcel.2011.11.010","title":"Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI","abstract":null,"journal":"Molecular Cell","year":2012,"id":47496,"datarank":7.710499295391658,"base_score":5.442417710521793,"endowment":5.442417710521793,"self_citation_contribution":0.8163626565782691,"citation_network_contribution":6.894136638813389,"self_endowment_contribution":0.8163626565782691,"citer_contribution":6.894136638813389,"corpus_percentile":null,"corpus_rank":null,"citation_count":230,"citer_count":200,"citers_with_citation_signal":184,"citers_with_endowment":184,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":219804,"name":"Donniphat Dejsuphong","orcid":null,"position":1,"is_corresponding":false},{"id":219805,"name":"Mark I.R. Petalcorin","orcid":null,"position":2,"is_corresponding":false},{"id":90539,"name":"Kay Hofmann","orcid":"0000-0002-2289-9083","position":3,"is_corresponding":false},{"id":121180,"name":"Shunichi Takeda","orcid":null,"position":4,"is_corresponding":false},{"id":219806,"name":"Simon J. Boulton","orcid":null,"position":5,"is_corresponding":false},{"id":219807,"name":"Alan D. D'Andrea","orcid":null,"position":6,"is_corresponding":false},{"id":219803,"name":"George-Lucian Moldovan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI","abstract":"Inappropriate homologous recombination (HR) causes genomic instability and cancer. In yeast, the UvrD family helicase Srs2 is recruited to sites of DNA replication by SUMO-modified PCNA, where it acts to restrict HR by disassembling toxic RAD51 nucleofilaments. How human cells control recombination at replication forks is unknown. Here, we report that the protein PARI, containing a UvrD-like helicase domain, is a PCNA-interacting partner required for preservation of genome stability in human and DT40 chicken cells. Using cell-based and biochemical assays, we show that PARI restricts unscheduled recombination by interfering with the formation of RAD51-DNA HR structures. Finally, we show that PARI knockdown suppresses the genomic instability of Fanconi Anemia/BRCA pathway-deficient cells. Thus, we propose that PARI is a long sought-after factor that suppresses inappropriate recombination events at mammalian replication forks.","is_dataset_classified":null,"base_score":5.442417710521793,"endowment":5.442417710521793,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22153967","pmcid":"PMC3267324","openalex_id":"https://openalex.org/W2124915114","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL048546","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01HL52725","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R37 HL052725","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01CA092584","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL052725","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01DK43889","title":null},{"funder_name":"Cancer Research UK","grant_id":"11581","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK043889","title":null}],"total_grants":8,"fwci":8.8787,"citation_percentile":0.98702389,"influential_citations":13,"citation_trend":[{"year":2012,"count":26},{"year":2013,"count":29},{"year":2014,"count":18},{"year":2015,"count":15},{"year":2016,"count":20},{"year":2017,"count":13},{"year":2018,"count":22},{"year":2019,"count":9},{"year":2020,"count":15},{"year":2021,"count":10},{"year":2022,"count":9},{"year":2023,"count":17},{"year":2024,"count":11},{"year":2025,"count":14},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1097276511008951/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1097276511008951/pdf","host_type":"BRONZE"},{"url":"http://www.cell.com/article/S1097276511008951/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276511008951?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276511008951?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.molcel.2011.11.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22153967","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3267324","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","CRISPR and Genetic Engineering","PARP inhibition in cancer therapy","Biology","Medicine","Animals","Carrier Proteins","Cell Line, Tumor","Chickens","DNA Repair","DNA-Binding Proteins","Gene Expression Regulation","Genomic Instability","HEK293 Cells","HeLa Cells","Homologous Recombination","Humans","Proliferating Cell Nuclear Antigen","Rad51 Recombinase"],"mesh_terms":["Animals","Carrier Proteins","Chickens","DNA Repair","DNA-Binding Proteins","Gene Expression Regulation","HeLa Cells","Humans","Proliferating Cell Nuclear Antigen","Genomic Instability","Cell Line, Tumor","Rad51 Recombinase","HEK293 Cells","Homologous Recombination","Hela Cells"],"keywords":["RAD51","Biology","Homologous recombination","Genome instability","Helicase","Replication protein A","DNA replication","DNA repair","Homologous chromosome","Proliferating cell nuclear antigen","Fanconi anemia","Replication factor C","Genetics","Molecular biology","Cell biology","DNA","Control of chromosome duplication","Gene","DNA damage","DNA-binding protein","RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T18:32:53.516673Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}